Downregulation of exosome-encapsulated miR-548c-5p is associated with poor prognosis in colorectal cancer

Journal of Cellular Biochemistry
Zhi-Yong PengBin Yan

Abstract

The role of circulating exosomal microRNAs (miRNAs) in colorectal cancer (CRC) has drawn more and more attention during the past few years. Previously, we have identified several specific miRNAs in serum exosomes as potential CRC biomarkers. However, little is known about the association between exosome-encapsulated miR-548c-5p and outcomes of patients with CRC. In the current study, the expression of serum exosomal miR-548c-5p was investigated by quantitative real-time polymerase chain reaction. Its correlation with CRC prognosis was estimated by Kaplan-Meier survival and log-rank tests. Cox regression analysis based on uni- and multivariate analyses was performed to estimate the relationship of exosome-encapsulated miR-548c-5p with the clinicopathological factors of patients with CRC. Reduced levels of serum exosomal miR-548c-5p were more significant in CRC patients with liver metastasis and at later TNM stage (III/IV tumor stages). Serum exosomal miR-548c-5p could inhibit the proliferation of CRC cells, while the precise molecular mechanisms warranted further elucidation. In addition, decreased levels of serum exosomal miR-548c-5p were independently associated with shorter overall survival in CRC adjusted by age, sex, tumor ...Continue Reading

References

Aug 3, 2002·Science·György Hutvágner, Phillip D Zamore
Mar 12, 2004·Genes & Development·John G Doench, Phillip A Sharp
Feb 16, 2007·PloS One·Jittima Piriyapongsa, I King Jordan
Mar 29, 2008·Science·Jennifer Couzin
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Tingming LiangChang Liu
Apr 27, 2013·Science·Jeremy E Wilusz, Phillip A Sharp
Sep 11, 2014·World Journal of Gastroenterology : WJG·Verena StiegelbauerMartin Pichler
Dec 31, 2014·Cancer Biomarkers : Section a of Disease Markers·Cillian ClancyMichael J Kerin
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 10, 2015·British Journal of Cancer·T MatsumuraK Mimori
Nov 26, 2015·International Journal of Molecular Sciences·Joe ThomasHui Ling
Feb 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shushan YanBeicheng Sun
Jan 17, 2017·Journal of Cellular Physiology·Abdullah MoridikiaJafar Salimian
Jun 21, 2017·International Journal of Molecular Sciences·Cécily LucasHang Thi Thu Nguyen
Jul 20, 2017·International Journal of Radiation Oncology, Biology, Physics·Bijaya MallaAlan Dal Pra
Jul 26, 2017·Trends in Cancer·Daniele V F Tauriello, Eduard Batlle

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Citations

Feb 5, 2019·Cancer Metastasis Reviews·Mariantonia LogozziStefano Fais
Mar 26, 2019·Expert Review of Molecular Diagnostics·Lili DuanDaiming Fan
Apr 2, 2019·Journal of Cellular Physiology·Jianxin GeXiaoyan Zhang
Oct 27, 2018·Journal of Cellular Biochemistry·Keqiu JiangLiming Wang
Feb 26, 2020·International Journal of Molecular Sciences·Amro BaassiriSally Temraz
Aug 5, 2020·Signal Transduction and Targeted Therapy·Biting ZhouShu Zheng
Nov 25, 2018·International Journal of Molecular Sciences·Ovidiu BalacescuAlexandru Irimie
Apr 20, 2019·Molecular Carcinogenesis·Neha JainBibekanand Mallick
Feb 2, 2019·World Journal of Clinical Cases·Chi-Hin Wong, Yang-Chao Chen
Jun 30, 2019·Cancers·Óscar Rapado-GonzálezLaura Muinelo-Romay
Aug 30, 2020·Biomedicines·Marco VacanteAntonio Biondi
Oct 9, 2019·Expert Review of Molecular Diagnostics·Margaritis AvgerisAndreas Scorilas
Jan 23, 2020·World Journal of Gastrointestinal Oncology·Tasuku Matsuoka, Masakazu Yashiro
Jan 6, 2021·International Journal of Molecular Sciences·Katiusse Alves Dos SantosVivian Nogueira Silbiger
Jan 6, 2021·Journal of Oral Biology and Craniofacial Research·Alieh FarshbafSeyed Abdolrahim Rezaee
Dec 19, 2020·Molecular Therapy. Nucleic Acids·Liaoran NiuDaiming Fan
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Aitor Rodriguez-CasanovaAngel Diaz-Lagares
Apr 4, 2021·Cancers·Enea FerlizzaMattia Lauriola
Jul 6, 2021·World Journal of Clinical Cases·Yvette UmwaliXin Zhang
Jul 19, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L YangG Hu
Jul 27, 2021·Expert Review of Molecular Diagnostics·Raheleh HeydariAnna Meyfour
Sep 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bowen LiHui Feng
Sep 9, 2020·Cancer Letters·Qingbin WuYong Peng

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