Downregulation of Fas ligand by shedding

Nature Medicine
M TanakaS Nagata

Abstract

Apoptosis-inducing Fas ligand (FasL) is a type II membrane protein, predominantly expressed in the activated T cells. FasL is cleaved by a putative metalloproteinase to produce a soluble form. Here, we blocked the shedding of human FasL by deleting its cleavage site. Although human Jurkat cells and mouse primary hepatocytes that express a low level of Fas were resistant to the soluble form of FasL, they were efficiently killed by membrane-bound FasL. Furthermore, soluble FasL inhibited cytotoxicity of the membrane-bound FasL. These results indicate that the membrane-bound form of FasL is the functional form and suggest that shedding of FasL is to prevent the killing of the healthy bystander cells by cytotoxic T cells.

References

Sep 11, 1990·Nucleic Acids Research·S Mizushima, S Nagata
Nov 17, 1995·Science·T S GriffithT A Ferguson
Dec 1, 1994·Experimental Cell Research·R NiS Nagata
Mar 1, 1995·The Journal of Experimental Medicine·H AraseT Saito
Mar 10, 1995·Science·S Nagata, P Golstein
Oct 19, 1995·Nature·D BellgrauR C Duke
Oct 19, 1995·Nature·T Yagami-HiromasaA Fujisawa-Sehara
Jun 1, 1995·European Journal of Immunology·D GrafR A Kroczek
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Oct 1, 1994·International Immunology·T TakahashiS Nagata
Mar 1, 1996·Nature Medicine·M TanakaS Nagata
Mar 15, 1996·The Journal of Biological Chemistry·F PietravalleJ F Gauchat
Feb 1, 1997·Nature Medicine·K SeinoH Yagita
Feb 7, 1997·Cell·S Nagata
Apr 4, 1997·Cell·A V ChervonskyL A Matis
Apr 1, 1997·Nature Medicine·T KondoS Nagata
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·J AllisonD L Vaux
Aug 18, 1997·The Journal of Experimental Medicine·N ItohY Matsuzawa

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Citations

Jul 18, 2001·Pathology Oncology Research : POR·I Peták, J A Houghton
Jan 22, 2005·Cancer Immunology, Immunotherapy : CII·Yuru MengDavid A Fishman
Oct 13, 1998·Cancer Immunology, Immunotherapy : CII·D B Chappell, N P Restifo
Jun 26, 2007·International Orthopaedics·Jong-Beom ParkK Daniel Riew
Aug 9, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jong-Beom ParkK Daniel Riew
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·Z Kondera-AnaszJ Sikora
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·S BouralexisA Evdokiou
Dec 1, 2006·Apoptosis : an International Journal on Programmed Cell Death·Kazuhisa NakanoYoshiya Tanaka
Apr 26, 2011·Apoptosis : an International Journal on Programmed Cell Death·Kinga Musiał, Danuta Zwolińska
Jul 1, 2011·Immunologic Research·Nikola L Vujanovic
Jan 24, 2004·Brain Research. Brain Research Reviews·Chulhee Choi, Etty N Benveniste
Feb 14, 2004·Cellular Immunology·Rita N BárciaJulie D McLeod
Oct 14, 2003·Biochemical Pharmacology·Andreas LinkermannOttmar Janssen
Jun 24, 2003·Journal of Molecular and Cellular Cardiology·Taro DateCanwen Jiang
Sep 5, 2002·Mathematical Biosciences·Steven D WebbReginald G Fish
Feb 13, 2001·Mechanisms of Ageing and Development·J D McLeod
May 5, 2001·Pharmacology & Therapeutics·K SharmaY F Shi
Nov 26, 2002·Journal of Neuroimmunology·Sophie Desplat-JégoJosé Boucraut
Dec 4, 2003·Early Human Development·Angeliki SarandakouAriadni Malamitsi-Puchner
Feb 19, 2002·Journal of the American College of Cardiology·Masumi ShimizuToshio Ogihara
Apr 27, 2000·Current Opinion in Immunology·G Screaton, X N Xu
Jun 25, 1998·Current Opinion in Immunology·D WallachM P Boldin
Oct 31, 1998·Current Opinion in Immunology·M E Peter, P H Krammer
Oct 31, 1998·Current Opinion in Immunology·J TschoppM Thome
Oct 31, 1998·Current Opinion in Immunology·P R WalkerP Y Dietrich
Feb 19, 2000·Current Opinion in Genetics & Development·M J Pinkoski, D R Green
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Beyer-SehlmeyerJ Bertram
Feb 14, 2002·Trends in Biochemical Sciences·Jean-Luc BodmerJürg Tschopp
Oct 18, 2003·Seminars in Immunology·Bryan C BarnhartMarcus E Peter

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis