Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging

Biochemical and Biophysical Research Communications
Hua Xu, Fan Liu

Abstract

Aging is known as a major risk factor for tendon disorders whereas the molecular mechanisms of age-related tendon disorders still remains unclear. Since tendon-derived stem/progenitor cells (TSPCs) play a vital role in tendon maintenance and healing, in this study we aimed to investigate the role of Forkhead box P1 (FOXP1) in aged TSPCs, we found that FOXP1 mRNA and protein levels were markedly decreased in the aged TSPCs. Moreover, overexpression of FOXP1 attenuates TSPCs aging, as confirmed by decreased of senescence-associated β-gal staining, as well as the senescence marker, p16INK4A. Conversely, FOXP1 depletion by siRNA promoted senescence in young TSPCs. Meanwhile, FOXP1 overexpression also restores the age-associated reduction of self-renewal, migration and differentiation of TSPCs. In addition, FOXP1 overexpression rescued decreased levels of E2F1, pRb and cyclin D1 in aged TSPCs, which suggested that FOXP1 regulates TSPCs aging through cellular senescence. These results indicate that FOXP1 plays a crucial role in TSPCs aging.

Citations

Feb 6, 2020·Frontiers in Genetics·Pauline Po Yee Lui, Chi Ming Wong
Oct 17, 2019·World Journal of Stem Cells·Guang-Chun DaiYun-Feng Rui
Dec 13, 2019·Stem Cells International·Yun-Feng RuiGuang-Chun Dai
Jan 18, 2021·British Medical Bulletin·Giuseppe GarganoNicola Maffulli
Mar 3, 2021·Stem Cell Reviews and Reports·Bing Wei, Jun Lu
Jan 15, 2019·Biochemical and Biophysical Research Communications·Stefanie KiderlenStefanie Sudhop

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