Abstract
Liver cancer is a major contributor to cancer-related death with poor survival for sufferers. Meanwhile, Hepatic B virus X protein (HBx) and XB130 are likely to participate in the pathogenesis of liver cancer. However, the detailed mechanism of HBx/XB130 in liver cancer remains to be further investigated. Our study explored the effects of HBx/XB130 on liver cancer progression. HBx and XB130 expression was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot. Overexpression of HBx and XB130 was found in liver cancer tissues and cells. Mechanistic study revealed that HBx could bind to and positively regulate XB130 in HepG2 cells. Subsequently, HBx expression was knocked down, while XB130 was overexpressed in HepG2 cells in order to observe the specific role of HBx/XB130 in liver cancer in vitro. Results of CCK-8, Transwell, wound healing, and colony formation assays suggested that HBx could mediate biological function of HepG2 cells by activating the XB130-mediated PI3K/AKT pathway. In summary, our data illustrate that inhibition of HBx effectively suppressed proliferation and metastasis and induced apoptosis of liver cancer cells, which might be partially reversed by XB130. HBx and ...Continue Reading
References
Apr 6, 2011·Cancer Research·Alla ArzumanyanMark A Feitelson
Dec 23, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Qiang ZuoWangjun Liao
Jul 19, 2012·Annals of Surgical Oncology·Atsushi ShiozakiEigo Otsuji
Jul 6, 2014·Scientifica·Xiao-Hui BaiMingyao Liu
Nov 5, 2014·Cancer Biology & Medicine·Xiao-Dong ZhangLi-Hong Ye
Dec 4, 2014·Nature·Lauren Gravitz
Mar 22, 2016·Biomedical Reports·Ruiyao ZhangChang Liu
Aug 6, 2017·Cancer Treatment Reviews·Filip Janku
Nov 4, 2017·Hepatology International·P Karayiannis
Feb 2, 2018·International Journal of Cancer. Journal International Du Cancer·Delphine Maucort-BoulchMartyn Plummer
Sep 25, 2018·Chinese Medical Journal·Guang-Ming LiYing-Chen Xu
Jul 20, 2019·BMC Cancer·Joseph TorresiElizabeth Vincan
Oct 31, 2019·Journal of Cellular Physiology·Farzad RahmaniSeyed M Hassanian
Dec 4, 2019·Molecular Cancer Research : MCR·Yu-Chin LiuChuck C-K Chao
Dec 4, 2019·International Journal of Oncology·Yuanyuan YeWeixian Chen
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 22, 2020·Cells·Oluwaseun Adebayo BamoduJo-Ting Tsai
Mar 29, 2020·Oncology Letters·Li-Rong LingDan Li
Apr 3, 2020·Cells·Marissa M MinorBetty L Slagle
May 24, 2020·Viruses·Young-Man LeeYeon-Soo Kim
May 30, 2020·Oncology Reports·Linlin YinZhaoning Ji
Jun 3, 2020·Nature Communications·Carla EllerThomas F Baumert
Jun 6, 2020·BMC Medicine·Guoxiang XieWei Jia
Feb 13, 2021·Polish Journal of Microbiology·Meryem Guvenir, Ayse Arikan