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Downregulation of Homer1b/c in SOD1 G93A Models of ALS: A Novel Mechanism of Neuroprotective Effect of Lithium and Valproic Acid

International Journal of Molecular Sciences

Dec 22, 2016

Hai-Zhi JiangHong-Lin Feng

Abstract

Mutations in the Cu/Zn superoxide dismutase (SOD1) gene have been linked to amyotrophic lateral sclerosis (ALS). However, the molecular mechanisms have not been elucidated yet. Homer family protein Homer1b/c is expressed widely in the central nervous system and plays important roles in ...read more

Mentioned in this Paper

SOD1 gene
HOMER1 gene
Founder Mice, Transgenic
In Vivo
Induced Gene Mutation
Wild Type Mouse
Bax protein
Bcl2l1 protein, rat
Visual Suppression
B-Cell Leukemia 2 Family Proteins
5
1
14
Paper Details
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Downregulation of Homer1b/c in SOD1 G93A Models of ALS: A Novel Mechanism of Neuroprotective Effect of Lithium and Valproic Acid

International Journal of Molecular Sciences

Dec 22, 2016

Hai-Zhi JiangHong-Lin Feng

PMID: 27999308

DOI: 10.3390/ijms17122129

Abstract

Mutations in the Cu/Zn superoxide dismutase (SOD1) gene have been linked to amyotrophic lateral sclerosis (ALS). However, the molecular mechanisms have not been elucidated yet. Homer family protein Homer1b/c is expressed widely in the central nervous system and plays important roles in ...read more

Mentioned in this Paper

SOD1 gene
HOMER1 gene
Founder Mice, Transgenic
In Vivo
Induced Gene Mutation
Wild Type Mouse
Bax protein
Bcl2l1 protein, rat
Visual Suppression
B-Cell Leukemia 2 Family Proteins
5
1
14

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Paper Details
References
  • References29
  • Citations
123
  • References29
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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