Abstract
Integrin-linked kinase (ILK) is a multifunctional serine/threonine kinase in cytoplasm. Recent studies showed that cancer patients with increased ILK expression had low survival, poor prognosis and increased metastasis. Although the causes of ILK overexpression remain to be fully elucidated, accumulating evidence suggests that its oncogenic capacity derives from its regulation of several downstream targets that provide cells with signals that promote proliferation, survival and migration. However, the mechanisms underlying tumor metastasis by ILK is still not fully understood. Epithelial–mesenchymal transition (EMT) is a critical event of cancer cells that triggers invasion and metastasis. We recently reported that knockdown of ILK inhibited the growth and induced apoptosis in human bladder cancer cells. Therefore, we postulate that ILK might involve in EMT. Here we further investigate the function of ILK with RNA interference in bladder cancer cells. Knockdown of ILK impeded an EMT with low Vimentin, Snail, Slug and Twist as well as high E-cadherin expression in vivo and vitro. In addition, we found that knockdown of ILK inhibited cell proliferation, migration and invasion as well as changed cell morphology, adhesion and rearr...Continue Reading
References
Mar 22, 2005·The International Journal of Biochemistry & Cell Biology·Jun-Xia ChenXiu-Yun Cui
Feb 14, 2006·Carcinogenesis·Zhiyong MiPaul C Kuo
May 9, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manjunath B JoshiThérèse J Resink
Jun 19, 2007·Molecular Cancer Therapeutics·Ronald P C WongGang Li
Dec 1, 2007·Interactive Cardiovascular and Thoracic Surgery·Stefan B WatzkaMichael R Müller
Feb 20, 2008·The Journal of Cell Biology·Andrew B FieldingShoukat Dedhar
Mar 8, 2008·EMBO Reports·Hervé AcloqueM Angela Nieto
Mar 15, 2008·Cancer Research·Paul C McDonaldShoukat Dedhar
May 3, 2008·Seminars in Cancer Biology·Lilly Y W Bourguignon
Sep 19, 2008·Journal of Cell Science·Paul C McDonaldShoukat Dedhar
Jul 16, 2009·Journal of Cellular and Molecular Medicine·Gang SongTianhui Hu
Jan 22, 2010·Virchows Archiv : an International Journal of Pathology·David F SchaefferDavid A Owen
Jun 16, 2010·Histopathology·Sofia PapanikolaouHelen Papadaki
Jun 23, 2010·Breast Cancer Research : BCR·Arusha OloumiShoukat Dedhar
Jun 23, 2010·CA: a Cancer Journal for Clinicians·Bruce L JacobsJames E Montie
Aug 26, 2010·Cancer Research·Sung-Young ShinKwang-Hyun Cho
Sep 10, 2010·PloS One·Mykola MaydanShoukat Dedhar
Sep 16, 2010·Cancer Research·Mathieu BoissanMarie-Lise Lacombe
Oct 7, 2010·Cancer Research·Masashi MuramatsuMasabumi Shibuya
Nov 3, 2010·Advances in Enzyme Regulation·Dorota GilPiotr Laidler
Nov 26, 2010·PloS One·Stuart J Netherton, Shirin Bonni
Dec 24, 2010·Australian Dental Journal·C X ZhouJ Gao
Feb 12, 2011·Cancer Letters·Min Jung JangJung Hwa Kim
Feb 26, 2011·Cell Adhesion & Migration·Taira Mayanagi, Kenji Sobue
Jun 18, 2011·The Journal of Biological Chemistry·Yorihisa ImanishiShi-Yuan Cheng
Aug 19, 2011·Journal of Biomedical Science·Shan-shan LiuYu Li
Sep 2, 2011·Cell & Bioscience·Yingying JingLixin Wei
Oct 5, 2011·The Journal of Biological Chemistry·Sujeenthar TharmalingamDavid R Hampson
Citations
May 25, 2013·Cell and Tissue Research·Xue YaoJun-Xia Chen
Sep 11, 2013·International Journal of Molecular Sciences·Spencer Larkin, Natasha Kyprianou
Jun 27, 2013·International Journal of Medical Sciences·Mingjing ZhaoXiaoge Wang
Sep 21, 2013·Journal of Molecular Histology·Feng LiangYunjie Wang
Apr 29, 2014·Experimental and Molecular Pathology·Dongmei XiongJunxia Chen
Jul 22, 2014·Trends in Pharmacological Sciences·Felicity M DavisGregory R Monteith
Aug 22, 2014·Applied Microbiology and Biotechnology·Rui XuDongzhi Wei
Dec 24, 2015·The International Journal of Biochemistry & Cell Biology·Jiajia YangManran Liu
Sep 24, 2015·Nature Reviews. Urology·Kim E M van KesselEllen C Zwarthoff
May 13, 2015·Journal of the Egyptian National Cancer Institute·Dalia M Abd El-RehimMaiiada H Nazmy
Jul 9, 2013·Biochimica Et Biophysica Acta·Paolo PaoliPaola Chiarugi
Dec 5, 2013·Journal of Receptor and Signal Transduction Research·Lei XiaoQian Liu
Jun 28, 2014·Urologic Oncology·Wu LiangWen-Lian Xie
Dec 17, 2014·Medical Oncology·Deyou TaoFeilin Cao
Dec 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen-Teish ChangChin-Shiu Huang
Sep 6, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Qiao-Mei ZhengLi-Hong Chen
Aug 27, 2016·Oncotarget·Cheolwon ChoiDavid M Helfman
Sep 1, 2016·Journal of Experimental & Clinical Cancer Research : CR·Xiang ZhuangJunxia Chen
Oct 11, 2012·Cancer Research·Chen-Hsien LiangTse-Ming Hong
May 10, 2020·European Journal of Cell Biology·Samira JavadiMojtaba Fathi
Mar 22, 2013·Journal of Cell Science·Steven M FrischBenjamin Cieply