Downregulation of integrin-linked kinase inhibits epithelial-to-mesenchymal transition and metastasis in bladder cancer cells

Cellular Signalling
Jun ZhuJun-Xia Chen

Abstract

Integrin-linked kinase (ILK) is a multifunctional serine/threonine kinase in cytoplasm. Recent studies showed that cancer patients with increased ILK expression had low survival, poor prognosis and increased metastasis. Although the causes of ILK overexpression remain to be fully elucidated, accumulating evidence suggests that its oncogenic capacity derives from its regulation of several downstream targets that provide cells with signals that promote proliferation, survival and migration. However, the mechanisms underlying tumor metastasis by ILK is still not fully understood. Epithelial–mesenchymal transition (EMT) is a critical event of cancer cells that triggers invasion and metastasis. We recently reported that knockdown of ILK inhibited the growth and induced apoptosis in human bladder cancer cells. Therefore, we postulate that ILK might involve in EMT. Here we further investigate the function of ILK with RNA interference in bladder cancer cells. Knockdown of ILK impeded an EMT with low Vimentin, Snail, Slug and Twist as well as high E-cadherin expression in vivo and vitro. In addition, we found that knockdown of ILK inhibited cell proliferation, migration and invasion as well as changed cell morphology, adhesion and rearr...Continue Reading

References

Mar 22, 2005·The International Journal of Biochemistry & Cell Biology·Jun-Xia ChenXiu-Yun Cui
May 9, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manjunath B JoshiThérèse J Resink
Jun 19, 2007·Molecular Cancer Therapeutics·Ronald P C WongGang Li
Dec 1, 2007·Interactive Cardiovascular and Thoracic Surgery·Stefan B WatzkaMichael R Müller
Feb 20, 2008·The Journal of Cell Biology·Andrew B FieldingShoukat Dedhar
Sep 19, 2008·Journal of Cell Science·Paul C McDonaldShoukat Dedhar
Jun 23, 2010·CA: a Cancer Journal for Clinicians·Bruce L JacobsJames E Montie
Feb 12, 2011·Cancer Letters·Min Jung JangJung Hwa Kim
Feb 26, 2011·Cell Adhesion & Migration·Taira Mayanagi, Kenji Sobue
Sep 2, 2011·Cell & Bioscience·Yingying JingLixin Wei
Oct 5, 2011·The Journal of Biological Chemistry·Sujeenthar TharmalingamDavid R Hampson

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Citations

Sep 11, 2013·International Journal of Molecular Sciences·Spencer Larkin, Natasha Kyprianou
Jul 22, 2014·Trends in Pharmacological Sciences·Felicity M DavisGregory R Monteith
Sep 24, 2015·Nature Reviews. Urology·Kim E M van KesselEllen C Zwarthoff
May 13, 2015·Journal of the Egyptian National Cancer Institute·Dalia M Abd El-RehimMaiiada H Nazmy
Jul 9, 2013·Biochimica Et Biophysica Acta·Paolo PaoliPaola Chiarugi
Dec 5, 2013·Journal of Receptor and Signal Transduction Research·Lei XiaoQian Liu
Dec 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen-Teish ChangChin-Shiu Huang
Sep 6, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Qiao-Mei ZhengLi-Hong Chen
Mar 22, 2013·Journal of Cell Science·Steven M FrischBenjamin Cieply

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