Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model

PloS One
Cheng-Yu YangYuan-Wu Chen

Abstract

Dysregulation of histone demethylase Jumonji-C domain-containing protein 5 (JMJD5) has been identified as a great effect on tumorigenesis. Silibinin is a commonly used anti-hepatotoxic drug and exhibits anticancer effect in various cancers. However, the antitumor mechanism between silibinin and JMJD5 in oral squamous cell carcinoma (OSCC) remains unclear. In this study, the clinical significance of JMJD5 on OSCC patients was assessed through tissue microarray. Furthermore, mice bearing patient-derived tumor xenografts (PDTXs) and tongue cancer cell lines were treated with silibinin and evaluated for tumor growth and JMJD5 expression. High expression of JMJD5 in oral cancer was significantly associated with tumor size (P = 0.0241), cervical node metastasis (P = 0.0001) and clinical stage (P = 0.0002), was associated with worse survival rate compared with that of the total cohort (P = 0.0002). Collectively the data indicate that JMJD5 expression may be suitable for detection of unfavorable prognosis in OSCC patients, based in part on its apparent role as a marker of metastasis. In addition, silibinin inhibits cancer growth in vitro and in PDTX models. Furthermore, metastasis-associated protein 1 (MTA1) could regulate the expressi...Continue Reading

References

Feb 19, 1998·The American Journal of Gastroenterology·K FloraK Benner
Feb 25, 2006·Journal of Dental Research·P-N ChenS-C Chu
Dec 6, 2006·Cancer Research·Paul RoepmanFrank C P Holstege
Oct 24, 2007·The Journal of Surgical Research·Fawn S HoganMorton S Kahlenberg
May 15, 2008·Journal of Agricultural and Food Chemistry·Sunny WallaceDanielle Julie Carrier
Apr 11, 2009·Oral Oncology·Yuan-Wu ChenHuey-Kang Sytwu
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Datsun A HsiaYoshihiro Izumiya
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 18, 2012·Nature Reviews. Clinical Oncology·John J TentlerS Gail Eckhardt
Jul 25, 2012·Trends in Endocrinology and Metabolism : TEM·Weibo Luo, Gregg L Semenza
Dec 6, 2012·Journal of Agricultural and Food Chemistry·Chiu-Mei LinKou-Gi Shyu
Dec 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hung-Jung WangWen-Ching Wang
Jul 1, 2014·Natural Product Reports·D BiedermannV Křen
Nov 2, 2014·Cancer Metastasis Reviews·Hezlin MarzookM Radhakrishna Pillai
Nov 7, 2014·Cancer Metastasis Reviews·Ekjot KaurShilpee Dutt
May 7, 2015·Cancer Treatment Reviews·Joaquim Bosch-Barrera, Javier A Menendez
Dec 3, 2015·Journal of Experimental & Clinical Cancer Research : CR·Yu ZhangZhihai Peng
Jul 1, 2016·Expert Review of Clinical Pharmacology·Xing-Xing ZhuQiang He
Oct 1, 2016·Oral Oncology·Nicoleta Sinevici, Jeff O'sullivan
May 13, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zachary R SchoepflinMakarand V Risbud
Jun 21, 2017·Chinese Journal of Cancer·Haneen AmawiAmit K Tiwari
Nov 29, 2017·Oncotarget·Hai ZouDong-Sheng Huang
Mar 3, 2018·Journal of Clinical Medicine·Juliet A Williams
Jun 6, 2018·Anti-cancer Agents in Medicinal Chemistry·Divya RawatRaj K Koiri
Sep 13, 2018·Anti-cancer Agents in Medicinal Chemistry·Christina LiakopoulouNatalia G Vallianou
Sep 16, 2018·Journal of Clinical Pharmacy and Therapeutics·Rashmi R Shah, Peter D Stonier
Sep 20, 2018·Journal of Agricultural and Food Chemistry·Angela R GuerraIola F Duarte
Sep 28, 2018·International Journal of Molecular Sciences·Miyako Kurihara-ShimomuraTadaaki Kirita
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuan YaoRui-Xin He
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hema Sree GnsMamatha Krishnamurthy

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Citations

Jul 3, 2021·Journal of Clinical Medicine·Nai-Wen Su, Yu-Jen Chen

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Methods Mentioned

BETA
nuclear translocation
xenograft
xenografts

Software Mentioned

GraphPad Prism
GENECards
Image J
GENECARD

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