PMID: 11321362Apr 26, 2001Paper

Downregulation of lipopolysaccharide-induced intercellular adhesion molecule-1 expression via EP2/EP4 receptors by prostaglandin E2 in human fibroblasts

Inflammation
K NoguchiI Ishikawa

Abstract

In the present study, the effect of prostaglandin E2 (PGE2) on intercellular adhesion molecule-1 (ICAM-1) expression in human gingival fibroblasts (HGF) stimulated with lipopolysaccharides (LPS) was investigated. LPS were isolated from periodontopathic bacteria, Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) and Porphyromonas gingivalis (P. gingivalis), by the phenol-water method and Escherichia coli (E. coli) LPS was used as a control. PGE2 significantly inhibited A. actinomycetemcomitans-, P. gingivalis- and E. coli-LPS-induced ICAM-1 expression. Next, of four PGE2 receptor subtypes (EP1, EP2, EP3 and EP4), we examined which subtype(s) was involved in inhibition of LPS-elicited ICAM-1 expression by PGE2. Eleven-deoxy-PGE1, a selective EP2/EP4 agonist, and butaprost, a selective EP2 agonist, attenuated A. actinomycetemcomitans-, P. gingivalis- and E. coli-LPS-elicited ICAM-1 expression, although butaprost was less potent than PGE2 and 11-deoxy-PGE1. Sulprostone, an EP1/EP3 agonist, and ONO-AP-324, an EP3 agonist, was inert to the LPS-elicited ICAM-1 expression. Furthermore, dibutyryl cAMP, a cAMP analogue, and forskolin, an adenylate cyclase activator, downregulated A. actinomycetemcomitans-, P. gingivalis- an...Continue Reading

Citations

Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideo K TakahashiMasahiro Nishibori
Feb 8, 2008·The Annals of Otology, Rhinology, and Laryngology·Reiko HattoriTakeshi Shimizu
Jan 12, 2007·Periodontology 2000·Kazuyuki Noguchi, Isao Ishikawa
Nov 19, 2011·FEMS Immunology and Medical Microbiology·Georgios N Belibasakis, Bernhard Guggenheim
Dec 22, 2017·PloS One·Daisuke KidoYuichi Izumi
Aug 19, 2010·The Laryngoscope·Ryan C BranskiDennis H Kraus

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