Downregulation of lncRNA TUG1 is involved in ankylosing spondylitis and is related to disease activity and course of treatment

Bioscience Trends
Xiaoyong LanJun Luo

Abstract

Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) promotes osteosarcoma, while its involvement in other bone diseases, such as ankylosing spondylitis (AS) is unknown. Expression of TUG1 in serum and open sacroiliac biopsies of AS patents and healthy controls was detected by real-time quantitative PCR (qRT-PCR). Ankylosing spondylitis disease activity score (ASDAS) system was used to evaluate disease activity. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of lncRNA TUG1 for AS. Chi-square test was performed to analyze the correlations between TUG1 expression and patients' clinicopathological data. Patients were divided into 2 groups (high and low expression groups) according to the median expression level of TUG1 and were followed-up for 5 years after discharge. Treatment courses and rehospitalization rate were compared between two groups. It was observed that TUG1 expression level was significantly lower in AS patients than in healthy controls in both serum and biopsies. Reduced expression level of TUG1 distinguished AS patients from controls. LncRNA TUG1 expression was significantly correlated with patients' smoking habits, disease activity, and course of disea...Continue Reading

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Citations

Dec 10, 2019·Journal of Orthopaedic Surgery and Research·Ye HanXi Xia
Aug 15, 2020·Frontiers in Molecular Biosciences·Junjie MaHailong Chen
Jan 3, 2020·Molecular and Cellular Biochemistry·Yehong LiMeihong Wang
Jun 7, 2019·BMC Musculoskeletal Disorders·Hongfa Zhong, Mingliang Zhong
Sep 10, 2021·Cell Proliferation·Hesuyuan HuangJianhao Lin

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