Downregulation of metabotropic glutamate receptor 1a in motoneurons after axotomy

Neuroreport
F J AlvarezR E Fyffe

Abstract

Axotomized motoneurons display drastic modifications in synaptic structure and function related to their disconnection from the periphery and establishment of a regenerative metabolic functional mode. The molecular basis of these modifications is not fully understood. Here we describe changes in metabotropic glutamate receptor 1a (mGluR1a)-immunoreactivity 3, 7 or 14 days after unilateral aciatic transection. mGluR1a-immunoreactivity was distributed throughout the somatic cytoplasm and somatodendritic membrane of uninjured motoneurons and was significantly reduced in axotomized motoneurons. This reduction was observed at 3 days and grew progressively over 2 weeks. These findings suggest that downregulation of mGluR1a could contribute to reduced excitatory neurotransmission in axotomized motoneurons.

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Citations

Sep 12, 2000·The Journal of Comparative Neurology·F J AlvarezT C Cope
Apr 29, 2005·Brain Research. Molecular Brain Research·Isabelle VassiasCatherine de Waele
Jul 26, 2002·Experimental Eye Research·RomAn BlancoPedro de la Villa
Jun 22, 2000·The Journal of Comparative Neurology·F J AlvarezP M Somohano
Jun 17, 2006·Journal of Applied Physiology·P GardinerC J Heckman
Nov 24, 2006·Journal of Neurophysiology·Arthur W EnglishXiang Yang Chen
Mar 16, 2004·Child Development·Elizabeth A CarlsonByron Egeland
Nov 23, 2017·Neurochemical Research·Reika KikuchiKazuyuki Nakajima
May 20, 2020·Frontiers in Molecular Neuroscience·Francisco J AlvarezTimothy C Cope

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