Dec 6, 2017

Downregulation of miR-141-3p promotes bone metastasis via activating NF-κB signaling in prostate cancer

Journal of Experimental & Clinical Cancer Research : CR
Shuai HuangYubo Tang


Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. miR-141-3p is an extensively studied miRNA in cancers and downregulation of miR-141-3p has been widely reported to be involved in the progression and metastasis of several human cancer types. However, the clinical significance and biological roles of miR-141-3p in bone metastasis of PCa are still unclear. miR-141-3p expression was examined in 89 non-bone metastatic and 52 bone metastatic PCa tissues by real-time PCR. Statistical analysis was performed to investigate the clinical correlation between miR-141-3p expression levels and clinicopathological characteristics in PCa patients. The biological roles of miR-141-3p in bone metastasis of PCa were evaluated both in vitro and a mouse intracardial model in vivo. Bioinformatics analysis, Western blot, luciferase reporter and miRNA immunoprecipitation assays were performed to explore and examine the relationship between miR-141-3p and its potential targets. Clinical correlation of miR-141-3p with its targets was examined in clinical PCa tissues. miR-141-3p expression is reduced in bone metastatic PCa tissues compared with non-bone metastatic PCa tissues. Low expression of miR-141-3p positively correla...Continue Reading

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Mentioned in this Paper

TNF receptor-associated factor 5
Real-Time Polymerase Chain Reaction
In Vivo
Prostatic Neoplasms
Metastasis from Malignant Tumor of Prostate
Non-Metastatic Neoplasm
Tumor Necrosis Factor Receptor
Western Blotting
Malignant Bone Neoplasm

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