Downregulation of miR-4443 and miR-5195-3p in ovarian cancer tissue contributes to metastasis and tumorigenesis

Archives of Gynecology and Obstetrics
Seyed Omar Ebrahimi, Somayeh Reiisi

Abstract

Ovarian cancer (OC) is one of the most fatal malignancies in women. High mortality rate may be due to problems with diagnosis in the early stages. The use of new biomarkers for faster diagnosis and selection of more efficient therapies is one of the main concerns in this area. miRNAs are non-coding and conserved molecules that are involved in regulating gene expression throughout different cell processes. Few studies have been conducted on the effects of miR-4443 and miR-5195-3p in cancer. Therefore, to determine the role of these miRNAs in OC, this study was directed to investigate the expression rate in OC tissue samples and its relationship with clinical factors. Expression levels of miR-4443 and miR-5195 were evaluated in 45 ovarian tumor and 45 ovarian non-tumor tissue samples paraffin embedded using qPCR. Expression was investigated by miRNA-specific primers and then statistical analysis was performed to determine the significance. In the next step, the relationship between clinopathologic factors and miRNA expression was investigated. The results showed that miR-4443 decreased in OC in metastatic and serous OC samples (0.154-fold, P < 0.0001). As well as, significant reduction in miR-5195-3p was observed in cancer sample...Continue Reading

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Citations

Oct 15, 2019·Frontiers in Cell and Developmental Biology·Alka SinghManisha Sachan
Mar 9, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jingwen XiaoMeiqin Yu

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