Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing

Molecular Medicine Reports
Dong-Yue WenHong Yang

Abstract

Abnormal expression of microRNA (miR) is associated with the occurrence and progression of various types of cancers, including papillary thyroid carcinoma (PTC). In the present study, the aim was to explore miR‑486‑5p expression and its role in PTC, as well as to investigate the biological function of its potential target genes. The expression levels of miR‑486‑5p and its clinicopathological significance were examined in 507 PTC and 59 normal thyroid samples via The Cancer Genome Atlas (TCGA). Subsequently, the results were validated using data from Gene Expression Omnibus (GEO) and ArrayExpress. Receiver operating characteristic and summary receiver operating characteristic curves were used to assess the ability of miR‑486‑5p in distinguishing PTC from normal tissue. Furthermore, potential miR‑486‑5p mRNA targets were identified using 12 prediction tools and enrichment analysis was performed on the encoding genes using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. The expression levels of miR‑486‑5p were consistently downregulated in PTC compared with in normal tissue across datasets from TCGA, GEO (GSE40807, GSE62054 and GSE73182) and ArrayExpress (E‑MTAB‑736). The results also demonstrated that miR‑486‑5p expres...Continue Reading

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Citations

Sep 10, 2020·International Journal of Molecular Sciences·Aistė KondrotienėBirutė Žilaitienė

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Datasets Mentioned

BETA
GSE57780
GSE62054
GSE73182
GSE40807
E-MTAB-736

Methods Mentioned

BETA
chip

Software Mentioned

RNA22v2
DAVID
microTv4
microT
STRING
ArrayExpress
Targetscan6
- rel2010
miRanda
doRiNA

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