Downregulation of N-myc and STAT Interactor Protein Predicts Aggressive Tumor Behavior and Poor Prognosis in Invasive Ductal Carcinoma

Journal of breast cancer
Ji Eun ChoiHan Suk Ryu

Abstract

We investigated the expression of the N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue and estimated its clinicopathologic significance as a prognostic factor. The expression levels and prognostic significance of NMI were also analyzed according to the molecular subgroup of breast cancers. Human NMI detection by immunohistochemistry was performed using tissue microarrays of 382 invasive ductal carcinomas. The correlation of NMI expression with patient clinicopathological parameters and prognostic significance was analyzed and further assessed according to the molecular subgroup of breast cancers. Moreover, in vitro experiments with 13 breast cancer cell lines were carried out. We also validated NMI expression significance in The Cancer Genome Atlas cohort using the Human Protein Atlas (HPA) database. Low NMI expression was observed in 190 cases (49.7%). Low NMI expression was significantly associated with the "triple-negative" molecular subtype (p < 0.001), high nuclear grade (p < 0.001), high histologic grade (p < 0.001), and advanced anatomic stage (p = 0.041). Patients with low NMI expression had poorer progression-free survival (p = 0.038) than patients with high NMI expression. Low NMI expression...Continue Reading

References

Oct 11, 2005·Journal of Molecular Biology·Beate SchlierfMichael Wegner
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
Apr 5, 2007·Molecular and Cellular Biochemistry·Keman ZhangYu-Chung Yang
Feb 27, 2009·Journal of Mammary Gland Biology and Neoplasia·Brett G HollierSendurai A Mani
Apr 10, 2009·International Journal of Cancer. Journal International Du Cancer·Rebecca A FillmoreRajeev S Samant
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Oct 5, 2012·Molecular Biology of the Cell·Zengpeng LiSi Qing Zhang
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Sep 2, 2014·Molecular Cancer·Jack W RostasRajeev S Samant
Jan 17, 2015·Oncoscience·Rajeev S Samant, Lalita A Shevde
Jul 7, 2015·Scientific Reports·Brandon J MetgeRajeev S Samant
Oct 4, 2017·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Jun 4, 2021·Oncogenesis·Heba Allah M AlsheikhRajeev S Samant

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
dissection
electrophoresis

Software Mentioned

HPA
SPSS

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.