Downregulation of PGI2 pathway in Pulmonary Hypertension Group-III patients

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Gulsev OzenXavier Norel

Abstract

Pulmonary hypertension (PH) is a progressive and life-threating lung disorder characterized by elevated pulmonary artery pressure and vascular remodeling. PH is classified into five groups, and one of the most common and lethal forms, PH Group-III is defined as PH due to lung diseases and/or hypoxia. Due to the lack of studies in this group, PH-specific drug therapies including prostacyclin (PGI2) analogues have not been approved or recommended for use in these patients. PGI2 is synthesized by the PGI2 synthase (PGIS) enzyme, and its production is determined by measuring its stable metabolite, 6-keto-PGF1α. An impaired PGI2 pathway has been observed in PH animal models and in PH Group-I patients; however, there are contradictory results. The aim of this study is to determine whether PH Group-III is associated with altered expression of PGIS and production of PGI2 in humans. To explore this hypothesis, we measured PGIS expression (by western blot) and PGI2 production (by ELISA) in a large variety of preparations from the pulmonary circulation including human pulmonary artery, pulmonary vein, distal lung tissue, pulmonary artery smooth muscle cells (hPASMC), and bronchi in PH Group-III (n = 35) and control patients (n = 32). Our ...Continue Reading

References

Jul 9, 1992·The New England Journal of Medicine·B W ChristmanJ E Loyd
Dec 1, 1989·American Journal of Respiratory Cell and Molecular Biology·D B BadeschK R Stenmark
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·R M TuderN F Voelkel
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·H OlschewskiW Seeger
Jul 4, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·C D FikeM Bousamra
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T A ParkerS H Abman
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Gerald SimonneauUNKNOWN Treprostinil Study Group
Jun 14, 2002·Cardiovascular Research·Friedrich C BlumbergMichael Pfeifer
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Candice D FikeSandra L Pfister
Nov 25, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Akihide ItohMasaharu Nishimura
May 10, 2008·American Journal of Respiratory and Critical Care Medicine·Ying-Ju LaiRalph Theo Schermuly
Sep 30, 2009·Respiration; International Review of Thoracic Diseases·Tarek A DernaikaGary T Kinasewitz
Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Emilia FalcettiLucie H Clapp
Feb 18, 2011·British Journal of Pharmacology·Michel FélétouPaul M Vanhoutte
Jul 16, 2011·International Journal of Clinical Practice. Supplement·J RyanS L Archer
Mar 13, 2014·American Journal of Respiratory and Critical Care Medicine·Robert S StearmanMark W Geraci
Apr 8, 2015·Therapeutics and Clinical Risk Management·Barbara L LeVarge
Jun 9, 2017·Nature Reviews. Cardiology·Edmund M T LauMarc Humbert
Dec 5, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Lan WangZhi-Cheng Jing
Dec 25, 2017·Lung·Mariana Faria-UrbinaAaron B Waxman
Aug 23, 2018·International Journal of Cardiology·Horst OlschewskiWerner Seeger
Dec 14, 2018·The European Respiratory Journal·Gérald SimonneauRogerio Souza
Sep 3, 2019·British Journal of Pharmacology·Gulsev OzenXavier Norel

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