Downregulation of plasma microRNA-29c-3p expression may be a new risk factor for diabetic retinopathy

Minerva endocrinologica
Bora TorusLevent TÖk

Abstract

Circulation miRNAs have emerged as new biomarkers for identifying and monitoring the microvascular complications of diabetes. The aim of this study is to evaluate the levels of five candidate miRNAs (miR-29c-3p, miR-18a, miR-31, miR-181 and miR-20a) in patients with diabetic retinopathy (DR) and their relationship with disease severity. The study included 31 diabetes patients without DR (NDR group), 68 patients with DR (DR group) and 30 healthy controls (HC group). Twenty-five of patients with DR were proliferative DR (PDR group) and 43 were non-proliferative DR (NPDR group) patients. Metabolic parameters and serum vascular endothelial growth factor (VEGF) levels of all participants were measured. Circulating miRNAs levels were determined by quantitative realtime PCR. Fundus examinations of all patients were performed by a single ophthalmologist. VEGF levels were significantly higher in the NDR and DR groups compared to HC group (p=0.011 and p=0.014, respectively). Plasma miR-29c-3p was downregulated in diabetic patients with retinopathy and without retinopathy. This downregulation was more prominent in diabetic patients without retinopathy compared to those with retinopathy (p=0.016). There was no significant difference in pla...Continue Reading

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