Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development

Gut
Y ShojiK Wakabayashi

Abstract

Involvement of prostaglandin E(2) (PGE(2)) receptors EP(1), EP(2), and EP(4) in the formation of aberrant crypt foci (ACF) and/or intestinal polyps has been suggested. In contrast, EP(3) appears to have no influence on the early stages of colon carcinogenesis. In the present study, we examined expression of PGE(2) receptor subtypes EP(1), EP(2), EP(3), and EP(4) in normal colon mucosa and colon cancers, and assessed the contribution of EP(3) to colon cancer development. mRNA expression of PGE(2) receptor subtypes EP(1), EP(2), EP(3), and EP(4) in normal colon mucosa and colon cancers in azoxymethane (AOM) treated mice and rats, and in humans, were examined by reverse transcription-polymerase chain reaction (RT-PCR), quantitative real time RT-PCR, and immunohistochemical analyses. Evaluation of the role of EP(3) was performed by intraperitoneal injection of AOM, using EP(3) receptor knockout mice. Effects of EP(3) receptor activation on cell growth of human colon cancer cell lines were examined using ONO-AE-248, an EP(3) selective agonist. Moreover, EP(3) expression in colon cancer cell lines was analysed with or without 5-aza-2'-deoxycytidine (5-aza-dC) treatment. Expression levels of EP(1) and EP(2) mRNA were increased in canc...Continue Reading

References

Jul 1, 1995·Gastroenterology·C E Eberhart, R N Dubois
Sep 30, 1994·Biochemical and Biophysical Research Communications·K TakeuchiK Abe
May 6, 1993·The New England Journal of Medicine·F M GiardielloG J Offerhaus
Dec 6, 1996·The Journal of Biological Chemistry·E Okuda-AshitakaO Hayaishi
Apr 18, 1998·Nature Medicine·D J Elder, C Paraskeva
Oct 21, 1998·Oncogene·N DhanasekaranD Onesime
Feb 13, 1999·Nature Genetics·P A Jones, P W Laird
Sep 10, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·K ZacharowskiC Thiemermann
Mar 24, 2000·Trends in Genetics : TIG·S B Baylin, J G Herman
May 29, 2003·Carcinogenesis·Toshihiko KawamoriKeiji Wakabayashi

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Citations

Sep 22, 2012·Seminars in Immunopathology·Masako Nakanishi, Daniel W Rosenberg
Oct 18, 2011·Cancer Metastasis Reviews·Claus Schneider, Ambra Pozzi
Oct 21, 2011·Cancer Metastasis Reviews·J E RundhaugS M Fischer
Oct 31, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hideki FuruyaToshihiko Kawamori
Dec 14, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tsuyoshi TajimaMasatoshi Hori
Dec 17, 2009·American Journal of Physiology. Renal Physiology·Yue ZhangBellamkonda K Kishore
Jan 27, 2010·BMC Gastroenterology·Nicolai KaltoftMark B Hansen
Jun 30, 2009·BMC Cancer·Glen A DohertyDesmond J Fitzgerald
Aug 27, 2013·International Journal of Molecular Sciences·Sally TemrazAli Shamseddine
Feb 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Manuel Sanchez-AlavezTamas Bartfai
Dec 3, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M Martinez-CutillasM T Martin
Jan 5, 2013·Critical Reviews in Oncology/hematology·William K K WuJun Yu
Sep 18, 2015·British Journal of Pharmacology·G O'Callaghan, A Houston
May 15, 2012·Progress in Lipid Research·Inês Cebola, Miguel A Peinado
Aug 26, 2011·Prostaglandins & Other Lipid Mediators·Emily R GreeneDipak Panigrahy
Feb 22, 2011·Gastroenterology·Michihiro MutohKeiji Wakabayashi
Oct 13, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Steven G GrayKenneth J O'Byrne
Sep 16, 2006·The Journal of Investigative Dermatology·Sabine BrouxhonAlice P Pentland
Aug 12, 2015·Gastroenterology·Dingzhi WangRaymond N DuBois
Dec 22, 2007·Prostaglandins & Other Lipid Mediators·Antoine T Chalfoun, Sawsan Ibrahim Kreydiyyeh
Apr 25, 2009·International Journal of Cancer. Journal International Du Cancer·Daniela WuttigManfred P Wirth
Aug 8, 2008·Basic & Clinical Pharmacology & Toxicology·Ahmed Soliman MosaNiels Bindslev
Feb 13, 2008·Journal of Cellular and Molecular Medicine·C-J HuangC-M Lin
Oct 6, 2007·International Journal of Cancer. Journal International Du Cancer·Marco BreinigMichael André Kern
Feb 10, 2007·International Journal of Cancer. Journal International Du Cancer·Annika GustafssonKent Lundholm
Oct 4, 2006·British Journal of Pharmacology·I DeyK Chadee

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