Abstract
To determine whether reduced sarcoplasmic reticulum (SR) Ca(2+)-adenosinetriphosphatase (ATPase) (SERCA2) activity contributes to delayed myocardial relaxation during chronic left ventricular hypertrophy (LVH) progression, LVH was produced in rats by abdominal aortic coarctation. Systolic and diastolic functions were assessed in vivo 8 and 16 wk after surgery, and compositional alterations in LV myocardium [SERCA2 concentration, myosin heavy chain (MHC) isoenzymes, and tissue collagen] were correlated with the development of prolonged isovolumic relaxation and impaired cardiac performance over time. Myocardial relaxation was prolonged in 8-wk banded rats, despite normal isovolumic systolic function and LV end-diastolic pressure (LVEDP). No significant alterations in SERCA2 protein, beta-MHC, or fibrillar collagen levels were observed at this early time point. In contrast, LV SERCA2, beta-MHC, and fibrillar collagen concentrations were all significantly altered in 16-wk banded rats. These late compositional changes were associated with reduced cardiac performance, as manifested by a significant elevation in LVEDP (14 +/- 2 mmHg). The 34% decrease in SERCA2 protein was associated with reduced SR Ca2+ uptake and an even greater re...Continue Reading
Citations
Jan 13, 1999·Circulation·M TajimaB H Lorell
Nov 26, 1999·Circulation Research·S M PogwizdD M Bers
Apr 17, 2002·Circulation·Martin E YoungHeinrich Taegtmeyer
Oct 31, 2002·Circulation·Lars RothermundReinhold Kreutz
Apr 15, 2005·American Journal of Physiology. Cell Physiology·Maria C HeidkampAllen M Samarel
Jan 5, 2002·Japanese Circulation Journal·K TakeuchiP J del Nido
Nov 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jo El J SchultzMuthu Periasamy
May 2, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Beatriz M R CarvalhoJosé W M Bassani
Dec 1, 1998·Circulation·M AngerJ L Samuel
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Allison L BayerAllen M Samarel
Nov 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jasmina VaragicBegoña López
Jun 6, 1998·Cardiovascular Research·R M PhillipsR A Altschuld
Jun 7, 2006·Circulation·Harald KöglerGerd Hasenfuss
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S Y BoatengK R Boheler
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·X ZhangJ Y Wei
Dec 2, 2004·Molecular and Cellular Biology·Brooke C HarrisonTimothy A McKinsey
Dec 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Mark R FowlerClive H Orchard
Aug 8, 2001·Circulation·A M GómezW J Lederer
Dec 13, 2005·Experimental Biology and Medicine·Mladen PavlovicSabina Gallati
Dec 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·José L PuglisiDonald M Bers
Oct 21, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Carl HaywardAlexander Lyon