Downregulation of splicing regulator RBFOX1 compromises visual depth perception

PloS One
Lei GuNatik Piri

Abstract

Rbfox1 is a splicing regulator that has been associated with various neurological conditions such as autism spectrum disorder, mental retardation, epilepsy, attention-deficit/hyperactivity disorder and schizophrenia. We show that in adult rodent retinas, Rbfox1 is expressed in all types of retinal ganglion cells (RGCs) and in certain subsets of amacrine cells (ACs), within the inner nuclear (INL) and ganglion cell (GCL) layers. In the INL, all Rbfox1-positive cells were colocalized with GABAergic ACs, however not all GABAergic ACs were immunostained for Rbfox1. In the GCL, a vast majority of GABAergic dACs were Rbfox1-immunopositive. Furthermore, all cholinergic starburst ACs (SACs) in the INL (type a) and in the GCL (type b) were Rbfox1 positive. The expression of Rbfox1 in the retina significantly overlapped with expression of Rbfox2, another member of Rbfox family of proteins. Rbfox2, in addition to RGCs and ACs, was also expressed in horizontal cells. In developing retinas at E12 and E15, Rbfox1 is localized to the cytoplasm of differentiating RGCs and ACs. Between P0 and P5, Rbfox1 subcellular localization switched from cytoplasmic to predominantly nuclear. Downregulation of Rbfox1 in adult Rbfox1loxP/loxP mice had no dete...Continue Reading

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Citations

Mar 7, 2020·Journal of Pineal Research·Hernán H DiéguezDamián Dorfman
Apr 7, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fang ShenGang Chen
Nov 5, 2019·Frontiers in Behavioral Neuroscience·Chloé FelgerolleOlivier Perche
Mar 12, 2021·Current Biology : CB·Howard C BooneAaron W McGee
Mar 7, 2021·International Journal of Molecular Sciences·Izarbe Aísa-MarínGemma Marfany

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Datasets Mentioned

BETA
GSE105084

Methods Mentioned

BETA
transgenic
PCR
RNA-seq

Software Mentioned

CBot
edgeR
project
R
Bioconductor package
DAVID Bioinformatics Resources
STAR

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