Abstract
Uncontrolled cell proliferation is the hallmark of cancer, and cancer cells have typically acquired damage to genes that directly regulate their cell cycles. The synthesis of DNA onto the end of chromosome during the replicative phase of cell cycle by telomerase may be necessary for unlimited proliferation of cells. Telomerase, a ribonucleoprotein enzyme is considered as a universal therapeutic target of cancer because of its preferential expression in cancer cells and its presence in 90 % of tumors. We studied the regulation of telomerase and telomerase reverse transcriptase catalytic subunit (TERT) by diclofenac and curcumin, alone and also in combination, in 1, 2-dimethylhydrazine dihydrochloride-induced colorectal cancer in rats. The relationship of telomerase activity with tumors suppressor proteins (p51, Rb, p21), cell cycle machinery, and apoptosis was also studied. Telomerase is highly expressed in DMH group and its high activity is associated with increased TERT expression. However, telomerase is absent or is present at lower levels in normal tissue. CDK4, CDK2, cyclin D1, and cyclin E are highly expressed in DMH as assessed by RT-PCR, qRT-PCR, Western blot, and immunofluorescence analysis. Diclofenac and curcumin over...Continue Reading
References
May 7, 1976·Analytical Biochemistry·M M Bradford
Dec 23, 1994·Science·N W KimJ W Shay
Jan 1, 1996·Annual Review of Biochemistry·C W Greider
Feb 19, 1998·Oncogene·C CayrolB Ducommun
May 10, 2000·Current Opinion in Cell Biology·K Collins
Aug 10, 2000·Journal of Neuro-oncology·K HaradaE Tahara
Aug 19, 2000·Nature·S E ArtandiR A DePinho
Nov 7, 2000·Oncogene·D XuP Pisa
Dec 5, 2000·Current Biology : CB·Y LiuL Harrington
Oct 26, 2001·Biochemical and Biophysical Research Communications·V M AdhamiN Ahmad
Jan 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Janusz BłasiakTomasz Pertyński
Jan 19, 2002·Genes & Development·Bing RenBrian David Dynlacht
Nov 19, 2002·Mutagenesis·Robert F Newbold
Mar 13, 2003·World Journal of Gastroenterology : WJG·Qi-Fu LiShui-Gen Hong
Jan 28, 2004·Cell·Thomas R Cech
Apr 6, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Béatrice MouilléFrançois Blachier
May 4, 2004·Molecular Biology of the Cell·Rena Oulton, Lea Harrington
Jun 11, 2004·Annual Review of Biochemistry·Agata Smogorzewska, Titia de Lange
Jun 29, 2004·The Journal of Pathology·Sunanda J ChatterjeeRichard J Cote
Aug 13, 2004·Nature·Eva HernandoCarlos Cordon-Cardo
May 19, 2005·Cancer Research·Andrei L Gartel, Senthil K Radhakrishnan
Jan 31, 2006·Cancer·Hua HeBenjamin Chun-Yu Wong
Jul 18, 2006·Biochemical and Biophysical Research Communications·Shankar Jagadeesh, Partha P Banerjee
Jun 16, 2007·Advances in Experimental Medicine and Biology·Shishir ShishodiaMadan M Chaturvedi
May 17, 2008·Cancer Science·Ying CaoRoger R Reddel
Sep 5, 2008·BMC Structural Biology·Laura PiccagliRoberto Gambari
Feb 25, 2009·Nature Reviews. Cancer·Marcos Malumbres, Mariano Barbacid
Dec 3, 2010·The Journal of Pathology·Amanda M GohDavid P Lane
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 10, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gulden DinizCanan Vergin
May 23, 2012·Biochemical and Biophysical Research Communications·Dorrah DeebSubhash C Gautam
May 23, 2012·Mechanisms of Ageing and Development·Grazyna MosieniakEwa Sikora
Nov 15, 2012·Cell Biochemistry and Biophysics·Vivek VaishSankar Nath Sanyal
Jan 25, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Saeid ShiraliMarzieh Moeinifard
Jul 17, 2013·Cell Biochemistry and Biophysics·Vivek VaishSankar Nath Sanyal
Oct 1, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hong-Tao ZhangQin-Xian Zhang
Citations
Feb 24, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Preety GhanghasS N Sanyal
May 18, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Giridhar MudduluruUlrike Stein
Jun 17, 2016·Clinical Proteomics·Gajanan SatheAditi Chatterjee
Oct 11, 2011·PloS One·Aníbal Valentín-AcevedoLori R Covey
Jul 24, 2007·Blood Cells, Molecules & Diseases·Francesca CorradiniBruno Calabretta
Oct 1, 2013·Cancer Letters·Ping YeThomas J Gonda
Jan 1, 2017·Journal of Cancer Prevention & Current Research·Karen L ChenZeynep Madak-Erdogan
Apr 26, 2019·Human & Experimental Toxicology·L A Méndez-GarcíaE J Córdova
Oct 24, 2018·Nutrients·Xiao-Yu XuHua-Bin Li
Feb 15, 2018·Medicine·Suhui LouQuancheng Kan
Apr 2, 2020·Cells·Camille JacquesBenjamin Ory
Oct 8, 2016·Oncotarget·Alberto IzzottiSilvio De Flora
Apr 8, 2020·Oncotarget·Patricia FerreiraMaria Del Pilar Estevez-Diz
Jul 19, 2017·Cancer Investigation·Shelly JainS N Sanyal
Feb 23, 2019·Nutrition Research and Practice·Phil-Kyung ShinSang-Woon Choi
Jan 12, 2019·Critical Reviews in Food Science and Nutrition·Sita Sharan PatelPriyal Jain
Oct 5, 2016·Oncology Letters·Linwei LiShixin Lu
May 8, 2020·Seminars in Cancer Biology·Anuradha KirtoniaManoj Garg
Jun 27, 2021·Phytotherapy Research : PTR·Korosh MorshediHamed Mirzaei