Downregulation of Tryptophan-related Metabolomic Profile in Rheumatoid Arthritis Synovial Fluid

The Journal of Rheumatology
Kwi Young KangJi Hyeon Ju

Abstract

Synovial fluid (SF) is one of the most important materials that reflect the pathophysiological process of arthritis. A metabolomic and lipidomic study of SF was performed with the aim of identifying tentative diagnostic markers or therapeutic candidates for rheumatoid arthritis (RA). SF was aspirated from 10 patients with RA and 10 patients with osteoarthritis (OA). RA SF and OA SF were collected and analyzed by ultraperformance liquid chromatography quadruple time-of-flight mass spectrometry. Associations among clinical variables, laboratory results, and metabolic profiles were investigated. The metabolic pathways for carnitine, tryptophan, phenylalanine, arachidonic acid, and glycophospholipid were significantly upregulated in OA SF. The metabolic pathways for taurine, cholesterol ester, and the β-oxidation of pristine acid, linolenic acid, and sphingolipid were activated more in RA SF than in OA SF. In particular, the tryptophan pathway, which comprises kynurenine, indoleacetic acid, indole acetaldehyde, and N'-formylkynurenine, was downregulated. Interestingly, the levels of tryptophan metabolites kynurenine and N'-formylkynurenine, which are involved in immune tolerance, were significantly lower in RA SF compared with OA S...Continue Reading

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Citations

Apr 5, 2016·Expert Review of Molecular Diagnostics·Ana MárquezF David Carmona
Mar 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lars-Oliver TykocinskiHanns-Martin Lorenz
Jan 10, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tristan MaerzKevin C Baker
Feb 23, 2018·Frontiers in Cellular and Infection Microbiology·Jing GaoYulong Yin
Aug 28, 2020·Frontiers in Immunology·Josephine BrownLaurence Morel
Sep 10, 2020·Biomolecules·Eleonora PanfiliMaria Teresa Pallotta

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