Abstract
This study evaluated the function and structural consequences of direct exposure of murine hepatoma MH-22a cells to polychromatic polarized light, to determine potential risk of malignancy following irradiation. Visible (VIS) and infrared (IR) light have been actively used for prevention and treatment of complications developed after conventional tumor therapy. However, the safety associated with this irradiation has not been determined. Polychromatic light (480-3400 and 385-750 nm), were used at different doses (4.8-38.4 J/cm(2)) to determine the viability, proliferation, and actin cytoskeleton in vitro by flow cytometry and confocal microscopy. Tumorogenic properties of cells were studied in vivo after transplantation in C3HA mice. Polychromatic light of a wide range of doses did not change the viability and proliferation of cells. After transplantation of cells irradiated with VIS-IR light (4.8 and 9.6 J/cm(2)) and VIS light (38.4 J/cm(2)) the tumor volume was lower in the treated group than in the control group in vivo. Transplantability of the irradiated cells also decreased, whereas survival of tumor-bearing mice increased. Three cell populations with different cytoskeleton structure were identified. After irradiation, th...Continue Reading
References
Apr 1, 1994·Cytometry·K RadosevićJ Greve
Dec 1, 1993·The Keio Journal of Medicine·M AbeT Kanno
Jan 1, 1996·Lasers in Surgery and Medicine·T I KaruR O Esenaliev
Sep 24, 1999·Lasers in Surgery and Medicine·R SrokaR Baumgartner
Sep 20, 2002·Brazilian Dental Journal·Antonio Luiz Barbosa PinheiroAldo Brugnera
Feb 8, 2003·Journal of Wound Care·L Medenica, M Lens
Jan 22, 2005·Lasers in Surgery and Medicine·Fang WangYun-Xia Wu
Apr 22, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·William PostenMurad Alam
Sep 13, 2005·Journal of Cellular Physiology·Xuejuan GaoXunbin Wei
Dec 17, 2005·Photomedicine and Laser Surgery·Jurema Lisboa Freire de CastroCristina Pacheco Soares
Mar 30, 2006·Lasers in Medical Science·Yi-Hsiang LiuYih-Shyong Lai
May 19, 2006·Photomedicine and Laser Surgery·Natalya A Zhevago, Kira A Samoilova
Sep 7, 2007·Photomedicine and Laser Surgery·A C M RennoE-L Laakso
Apr 16, 2008·Tsitologiia·N A FilatovaV A Ivanov
Nov 26, 2009·BMC Cancer·Lúcio FrigoRodrigo A B Lopes-Martins
Aug 9, 2011·Nature Reviews. Cancer·Sarah Seton-Rogers
Jan 29, 2013·Biochemical Pharmacology·Ji Hye KimJae Youl Cho
Citations
Aug 31, 2016·Photomedicine and Laser Surgery·Nickolay A KnyazevNatalia A Filatova
Feb 6, 2020·Laser Therapy·Natalia V KalmykovaKira A Samoilova
Aug 8, 2021·International Journal of Molecular Sciences·Nickolay A KnyazevNatalia A Filatova