Downregulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats

British Journal of Pharmacology
S KagotaM Kunitomo

Abstract

1. Cyclic guanosine monophosphate (cyclic GMP)-mediated mechanism plays an important role in vasodilatation and blood pressure regulation. We investigated the effects of high salt intake on the nitric oxide (NO) - cyclic GMP signal transduction pathway regulating relaxation in aortas of spontaneously hypertensive rats (SHR). 2. Four-week-old SHR and normotensive Wistar-Kyoto rats (WKY) received a normal salt diet (0.3% NaCl) or a high salt diet (8% NaCl) for 4 weeks. 3. In aortic rings from SHR, endothelium-dependent relaxations in response to acetylcholine (ACh), adenosine diphosphate (ADP) and calcium ionophore A23187 were significantly impaired by the high salt intake. The endothelium-independent relaxations in response to sodium nitroprusside (SNP) and nitroglycerin were also impaired, but that to 8-bromo-cyclic GMP remained unchanged. On the other hand, high salt diet had no significant effects on the relaxations of aortic rings from WKY. 4. In aortas from SHR, the release of NO stimulated by ACh was significantly enhanced, whereas the production of cyclic GMP induced by either ACh or SNP was decreased by the high salt intake. 5. Western blot analysis showed that the protein level of endothelial NO synthase (eNOS) was slig...Continue Reading

References

Apr 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·V Karr-Dullien, E Bloomquist
Jan 1, 1991·Hypertension·G H Williams, N K Hollenberg
Feb 1, 1987·Computer Methods and Programs in Biomedicine·Z W Kaminski, E F Domino
Sep 1, 1980·The American Journal of Medicine·T FujitaC S Delea
Aug 1, 1995·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·E Nava, T F Lüscher
Mar 1, 1996·Hypertension·M H Weinberger
Jul 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·E M MervaalaH Karppanen
Nov 14, 1998·Journal of Hypertension·K MatrouguiD Henrion
Feb 5, 1999·Reviews of Physiology, Biochemistry and Pharmacology·D Koesling, A Friebe
Mar 12, 1999·Journal of Molecular and Cellular Cardiology·I Fleming, R Busse
Mar 12, 1999·Journal of Molecular and Cellular Cardiology·C M Boulanger
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Aug 18, 2004·Neurochemistry International·Doris KoeslingAndreas Friebe

❮ Previous
Next ❯

Citations

Aug 19, 2003·European Journal of Pharmacology·Olusoga SofolaAdebayo Oyekan
Sep 13, 2003·European Journal of Pharmacology·Dileep Kumar RohraYasushi Ohizumi
Apr 3, 2008·The Journal of Biological Chemistry·Iraida G SharinaFerid Murad
Mar 21, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Grzegorz PiechaMarie-Luise Gross-Weissmann
Nov 24, 2004·Clinical and Experimental Pharmacology & Physiology·Oa SofolaMj Drinkhill
Jan 5, 2007·Clinical and Experimental Pharmacology & Physiology·Satomi KagotaKazumasa Shinozuka
Sep 12, 2012·Oxidative Medicine and Cellular Longevity·S A MuhammadY Adamu
Oct 6, 2012·Journal of Cell Science·Xiaojian XuYuansheng Gao
Nov 29, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P Clifton
Mar 7, 2007·British Journal of Pharmacology·C GerassimouA Papapetropoulos
Jul 5, 2015·Life Sciences·Kana MaruyamaKazumasa Shinozuka
Sep 21, 2013·The Journal of Urology·Luiz O LeiriaEdson Antunes
Feb 27, 2016·The Journal of Physiology·Dan Li, David J Paterson
Mar 20, 2018·Journal of Cardiovascular Pharmacology·Lebogang MokotediAletta M E Millen
Jul 26, 2003·Circulation Research·Andreas Friebe, Doris Koesling
Apr 27, 2011·Journal of Hypertension·Sébastien FoulquierJeffrey Atkinson
Jul 29, 2005·American Journal of Physiology. Renal Physiology·Yingrui WangHarm Peters
Dec 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magali CordaillatBernard Jover
Dec 25, 2008·The American Journal of Clinical Nutrition·Kacie M DickinsonPeter M Clifton
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Satomi KagotaMasaru Kunitomo
May 28, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jessica R C PriestleyJulian H Lombard
Feb 5, 2003·Canadian Journal of Physiology and Pharmacology·R R EttarhS A Adigun
Dec 8, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Jessica R C PriestleyJulian H Lombard
Dec 11, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Andreas M BeyerJulian H Lombard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.