Abstract
Previously, we reported that genomic loss of 14q occurs more frequently in high-grade than in low-grade clear cell renal cell carcinomas (ccRCCs), and has a significant impact on the levels of expression of genes located in this region, suggesting that such genes may be involved in the malignant transformation of ccRCCs. Here, we found that six of the genes located in the minimal common region of 14q loss were significantly downregulated in high-grade ccRCCs due to copy number loss. Using a dataset from The Cancer Genome Atlas Research Network, we found that downregulation of one of these six genes, WDR20, was significantly associated with poorer outcome in patients with ccRCC, suggesting that WDR20 downregulation may be involved in the malignant transformation of ccRCCs. In functional assays, exogenous WDR20 significantly inhibited the growth of RCC cell lines and induced apoptosis. Interestingly, the phosphorylation levels of ERK and protein kinase B/AKT, which reportedly contribute to the malignant phenotype of RCC cells, were clearly reduced by exogenous expression of WDR20. Thus, our data suggest that downregulation of WDR20 due to 14q loss may be involved in the malignant transformation of ccRCCs, in part through activati...Continue Reading
References
Oct 1, 1982·The American Journal of Surgical Pathology·S A FuhrmanC Limas
May 14, 1999·Trends in Biochemical Sciences·T F SmithE J Neer
Oct 19, 2006·Seminars in Oncology·Victor E Reuter
Jan 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kohei ShomoriMasatsugu Moriyama
Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Jul 31, 2007·Critical Reviews in Oncology/hematology·Enrichetta CorgnaPieter H M De Mulder
Oct 9, 2007·The Journal of Pathology·T YoshimotoM Moriyama
Feb 20, 2008·British Journal of Cancer·L CampbellD F R Griffiths
Jan 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tobias KlatteAllan J Pantuck
Jun 16, 2009·Cancer·Lee CampbellMark Gumbleton
Feb 12, 2010·The Journal of Biological Chemistry·Younghoon KeeAlan D D'Andrea
Nov 26, 2010·Helicobacter·Carlos ResendeJosé C Machado
Apr 2, 2011·Genes, Chromosomes & Cancer·Salwati ShuibEamonn R Maher
Jul 20, 2011·The Journal of Biological Chemistry·Makoto NaganoMotoharu Seiki
Aug 11, 2011·Current Clinical Pharmacology·Holleh D Husseinzadeh, Jorge A Garcia
Dec 22, 2011·BMC Cancer·Keiko MatsuuraMasatsugu Moriyama
Mar 7, 2012·Oncogene·X LiT Gao
May 17, 2012·Cancer Discovery·Ethan CeramiNikolaus Schultz
Mar 2, 2013·BMC Cancer·Anja BruchmannDanilo Maddalo
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
May 22, 2013·PloS One·Zhiqing FangZhaoxu Liu
Jun 25, 2013·Nature·UNKNOWN Cancer Genome Atlas Research Network
Sep 24, 2013·The Journal of Biological Chemistry·Urszula L BurskaCraig N Robson
Oct 23, 2013·The Journal of Biological Chemistry·Narmadha Reddy Gangula, Subbareddy Maddika
Sep 13, 2014·Oncotarget·Urszula L McClurgCraig N Robson
Oct 16, 2014·Cancer Medicine·Takahiro NarimatsuMasatsugu Moriyama
Mar 19, 2015·BMC Cancer·Tomoya MizunoKen-Ichiro Yoshida
May 21, 2015·American Society of Clinical Oncology Educational Book·Axel BexMartin Voss
Citations
Jul 7, 2019·Oncogene·Blanca MajemAnna Santamaría
Oct 28, 2018·Nature Communications·Daniele RamazzottiArend Sidow
Jul 17, 2018·Oncology Letters·Ting LuoLianghong Yin
Dec 8, 2020·PeerJ·Yan WangWei Zhao
Feb 1, 2020·Pharmacology & Therapeutics·Elena MariottoSanja Aveic
Feb 27, 2021·Computational Biology and Chemistry·Feng LiZhiyu Wang
Apr 4, 2021·Life·Kuokuo LiBin Li
Apr 11, 2021·Genomics·Yuenan LiuXiaoping Zhang
May 27, 2021·The Journal of International Medical Research·Jing-Hang MaZhen Feng
Aug 24, 2018·Gene·Feng LiuXiaofeng Wang
Nov 16, 2021·Molecular Medicine Reports·Hua-Chuan Zheng, Hua-Mao Jiang