PMID: 9176077Apr 1, 1997Paper

Down's syndrome is strongly associated with coeliac disease

Gut
L GaleJ M Duggan

Abstract

There is evidence of an increased prevalence of coeliac disease in Down's syndrome. To investigate the association, patients with Down's syndrome and matched controls were examined. Fifty nine patients with Down's syndrome residing in government institutions in the Hunter region of New South Wales were studied. Four were excluded (terminally ill = 1, uncooperative = 3). Each of 55 patients was matched for age, sex, and residence with a control patient. Patients with both positive IgA and IgG antigliadin antibodies were considered for endoscopical duodenal biopsy. Twenty one patients and two controls had raised IgA and IgG antibodies (chi 2 = 19.4; p < 0.001). Tissue was obtained in 18 patients. Two had characteristic flat, five pronounced lymphocytic infiltration not diagnostic of coeliac disease, two giardiasis, and eight were normal. In one the tissue was not suitable for analysis. There were few differences between the subgroups in their anthropomorphic, biochemical, or haematological findings. The prevalence of coeliac disease in these 51 patients with Down's syndrome is at least two (3.9%; 95% confidence interval (95% CI) 0%-9.2%) and could be as many as seven (13.7%; 95% CI 4.3%-23.2%). In this community the prevalence of...Continue Reading

Citations

Aug 9, 2003·Lancet·Peter H R Green, Bana Jabri
May 3, 2012·Seminars in Immunopathology·Kimberly P Newton, Shereen A Singer
Jul 14, 2012·Indian Journal of Pediatrics·Abdus Sami BhatMadhulika Kabra
Apr 11, 2001·European Journal of Gastroenterology & Hepatology·J CarnicerJ Artigas
Jun 15, 2010·European Journal of Gastroenterology & Hepatology·Rute M CerqueiraManuel R Correia
Jul 30, 2011·European Journal of Gastroenterology & Hepatology·Kate Emma EvansDavid S Sanders
Jul 31, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Sandeep NijhawanSubhash Nepalia
Sep 25, 2001·Journal of Pediatric Gastroenterology and Nutrition·M BonamicoUNKNOWN SIGEP (Italian Society of Pediatric Gastroenterology and Hepatology) and Medical Genetic Group
Feb 9, 2005·Journal of Pediatric Gastroenterology and Nutrition·Tony HanssonAnders Dannaeus
Jul 19, 2013·Journal of Pediatric Gastroenterology and Nutrition·Ketil StørdalLars C Stene
Apr 5, 2003·Best Practice & Research. Clinical Gastroenterology·Ranjana Gokhale, Barbara S Kirschner
Feb 13, 2013·The Journal of Pediatrics·Karl MårildJonas F Ludvigsson
Oct 22, 2008·Pediatric Clinics of North America·Melissa A Davidson
Aug 13, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Ozgur CoguluCihangir Ozkinay
Sep 10, 2003·Pathology·Richard C W WongStephen Adelstein
Sep 27, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F CataldoG Corsello
Oct 22, 2010·The Journal of Pediatrics·Nadia SattarThomas Wilson
Oct 27, 2006·Diabetes·Kathleen M GillespieJulian P H Shield
Apr 30, 2015·United European Gastroenterology Journal·Jonas F LudvigssonJoseph A Murray
Jun 6, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Raanan ShamirMoshe Leshno
Oct 28, 2015·Nutrients·Rachele CiccocioppoLuis Rodrigo
Feb 1, 2011·Cellular & Molecular Immunology·U Volta, V Villanacci
Feb 24, 2001·The American Journal of Gastroenterology·K J MatherD A Hanley
Aug 12, 2017·World Journal of Clinical Cases·Momcilo PavlovicMarko Bukurov
Oct 11, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ruud H J VerstegenMaaike A A Kusters
Aug 7, 2017·Journal of the Endocrine Society·Alexandra E ButlerPeter C Butler
Jul 25, 2019·BMC Medicine·Giacomo CaioAlessio Fasano
May 14, 2004·The Medical Journal of Australia·John M Duggan
Nov 17, 2020·Journal of Paediatrics and Child Health·Jonathan Bishop, Madhur Ravikumara
Sep 7, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Elena Crehuá-GaudizaCecilia Martínez-Costa
Sep 16, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·N P Kennedy, C Feighery
Jan 23, 2004·La Revue de médecine interne·S LepersS Dubucquoi

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