Downstaging and Histological Effects Might Be Reliable Predictors of the Efficacy of DOC+CDDP+5-FU (DCF) as Neoadjuvant Therapy for Stage III or Borderline Resectable Esophageal Cancer: a Single Institute Experience.

Journal of Gastrointestinal Cancer
Kazuma KobayashiSusumu Eguchi

Abstract

In Japan, two courses of CDDP+5-FU (CF) therapy followed by surgery are accepted as a standard treatment for stage II/III esophageal cancer (EC) based on the results of the JCOG9907 trial. To gain a better survival, benefit especially for stage III patients in comparison with CF therapy, a three-arm phase III trial (neoadjuvant setting: CF vs. CF + radiation vs. DOC+CF [DCF]) is ongoing. We have aggressively performed DCF therapy for stage III or IV patients since October 2014. We herein review the outcomes of DCF therapy. We retrospectively reviewed the cases of 27 patients with stage III or IV EC (male, n = 24; female, n = 3; median age, 70.0 years) who received DCF therapy. The response rate was 48.1%. Downstaging was achieved over the course of treatment in 14 patients (51.9%). Twenty-six patients transitioned to surgery, with 25 receiving R0 resection. DCF-treated patients who achieved downstaging showed significantly longer relapse-free survival (RFS) than those without downstaging (p = 0.0002). DCF-treated patients with a grade ≥ 1b histological effect showed significantly longer RFS than those with a grade < 1b effect (p = 0.0282). The multivariate analysis showed that downstaging was the only factor significantly assoc...Continue Reading

References

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May 14, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·B LinotO Capitain
Jul 22, 2014·Cancer Science·Shuichi HironakaUNKNOWN Japan Esophageal Oncology Group/Japan Clinical Oncology Group
Jan 27, 2015·Esophagus : Official Journal of the Japan Esophageal Society·Hiroyuki KuwanoAkio Yanagisawa
Jan 24, 2017·Esophagus : Official Journal of the Japan Esophageal Society·UNKNOWN Japan Esophageal Society
Jan 24, 2017·Esophagus : Official Journal of the Japan Esophageal Society·UNKNOWN Japan Esophageal Society
Sep 2, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Yuko KitagawaMasahiro Yoshida
Sep 2, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Yuko KitagawaMasahiro Yoshida

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