Downstaging colorectal liver metastases by concomitant unilateral portal vein ligation and selective intra-arterial chemotherapy

The British Journal of Surgery
Nazia SelznerP-A Clavien

Abstract

Although selective intrahepatic arterial chemotherapy successfully downstaged irresectable colorectal liver metastases in a previous study, curative resection was rarely possible, as the remnant healthy liver volume was inadequate. This pilot study evaluated the efficacy of concomitant unilateral portal vein ligation and selective intrahepatic arterial chemotherapy in downstaging such tumours. The study included 11 patients with irresectable colorectal liver metastases. Selective intrahepatic arterial chemotherapy was delivered using a subcutaneous pump, and each patient underwent concomitant unilateral portal vein ligation of the hemiliver judged to have the higher tumour load. Chemotherapy involved serial administration of floxuridine for 2 weeks every 4 weeks. All patients developed significant atrophy of the hemiliver subjected to portal vein ligation and contralateral hypertrophy. There was no increase in tumour load within 6 months of therapy, and the load decreased by 60 per cent in the hemiliver ipsilateral to the ligated vein. At 3 months, six of 11 patients showed a significant response to chemotherapy. In four patients, downstaging allowed curative resection after only three cycles of chemotherapy. These patients sur...Continue Reading

References

Oct 1, 1986·World Journal of Surgery·H KinoshitaS Kubo
Jan 1, 1995·World Journal of Surgery·J ScheeleM Paul
Mar 1, 1996·Archives of Surgery·H J WaneboC Soderberg
Mar 27, 1998·American Journal of Surgery·R BrancatisanoN Habib
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ImamuraS Kawasaki
Aug 12, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GiacchettiF Lévi
Aug 18, 1999·Annals of Surgery·T C CollinsS F Khuri
Feb 13, 2001·The British Journal of Surgery·E K AbdallaJ N Vauthey
Feb 24, 2001·Journal of the American College of Surgeons·J MelendezL H Blumgart
Feb 1, 2003·Annals of Surgery·Olivier FargesAlain Sauvanet
May 2, 2003·Annals of Surgery·Alan W HemmingJean-Nicolas Vauthey
Dec 14, 2004·Radiology·Donatella R Di StefanoJean-Robert Delpero
Oct 11, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Felix DahmPierre-Alain Clavien

❮ Previous
Next ❯

Citations

Jun 26, 2009·Journal de chirurgie·K SlimP Valleur
Apr 10, 2013·Nature Reviews. Gastroenterology & Hepatology·Chetana LimMarc Pocard
Jun 1, 2008·Seminars in Interventional Radiology·Dominique EliasThierry de Baere
Apr 13, 2007·The New England Journal of Medicine·Pierre-Alain ClavienRolf Graf
Nov 2, 2011·Annals of Surgery·Kuno LehmannPierre-Alain Clavien
Dec 4, 2008·Annals of Surgical Oncology·Wilmar de GraafThomas M van Gulik
Apr 16, 2009·La Radiologia medica·B BarbaroL Bonomo
Feb 9, 2012·International Journal of Surgical Oncology·Ashraf J HaddadSteven C Cunningham
Jan 28, 2009·World Journal of Surgery·Stefan BreitensteinPierre Alain Clavien
Sep 21, 2007·Cancer Investigation·Rebekah R White, William R Jarnagin
May 9, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R RoblesP Parrilla
Mar 3, 2009·American Journal of Surgery·Hai Liu, Shaihong Zhu
Aug 30, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G GarceaG J Maddern
Nov 6, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S Benoist, B Nordlinger
Jan 24, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Katarzyna FurrerPierre-Alain Clavien
Jul 5, 2011·The British Journal of Surgery·J S HammondD N Lobo
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre-Alain ClavienAshraf Mohammad El-Badry
May 9, 2012·Journal of Surgical Oncology·Stefan Heinrich, Hauke Lang
Dec 17, 2008·Magyar sebészet·Péter Kupcsulik
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernhard C PestalozziPierre-Alain Clavien
Feb 24, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Markus SelznerPierre-Alain Clavien

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.