Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages

Human Vaccines & Immunotherapeutics
Petra KrambergerAleš Štrancar

Abstract

Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is characterized by complexity of the starting material, number of purification methods to choose from, regulations that are setting the frame for the final product and analytical methods for upstream and downstream monitoring. This review gives an overview on the nanoplex downstream challenges and chromatography based analytical methods for efficient monitoring of the nanoplex production.

References

Mar 1, 1997·Human Gene Therapy·P W ShabramS Sutjipto
Sep 19, 1998·Journal of Chromatography. a·Y YuanC N Oliver
Jun 8, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·V KlyushnichenkoE Harmsen
Oct 6, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·J TransfiguracionA Kamen
Jul 20, 2002·Advances in Biochemical Engineering/biotechnology·Ales StrancarRoman Necina
Nov 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Julia TransfiguracionAmine Kamen
Apr 20, 2005·International Journal of Cardiology·Y Joseph WooH Lee Sweeney
May 16, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Teresa RodriguesPedro E Cruz
Sep 9, 2006·Journal of Biotechnology·C PeixotoP M Alves
Jan 24, 2007·Journal of Chromatography. a·E I Trilisky, A M Lenhoff
Jun 26, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·F SmrekarA Strancar
Aug 19, 2007·Journal of Pharmaceutical and Biomedical Analysis·Parminder Singh ChahalAmine Kamen
Jul 18, 2008·Journal of Pharmaceutical and Biomedical Analysis·Julia TransfiguracionAmine Kamen
Nov 21, 2008·Journal of Chromatography. a·Ion Gutiérrez-AguirreMaja Ravnikar
Feb 6, 2009·Biotechnology Progress·Cristina PeixotoPaula M Alves
Mar 2, 2010·Journal of Virological Methods·Petra KrambergerMatjaz Peterka
Dec 3, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Julia TransfiguracionAmine A Kamen
Jan 18, 2011·Journal of Chromatography. a·Franc SmrekarAleš Podgornik
Mar 29, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dubravko ForcicAleš Strancar
Jun 8, 2011·Journal of Separation Science·Franc SmrekarAleš Podgornik
Dec 3, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Claire S BurdenDaniel G Bracewell
Jul 18, 2012·Human Gene Therapy Methods·María Mercedes SeguraMiguel Chillón
Sep 1, 2012·Human Gene Therapy Methods·Vanessa BandeiraManuel J T Carrondo

❮ Previous
Next ❯

Citations

Feb 27, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Caleb AcquahClarence M Ongkudon
Jun 27, 2017·Nature Reviews. Microbiology·Jeroen De SmetRob Lavigne
Jul 18, 2019·Critical Reviews in Clinical Laboratory Sciences·Mansour PoorebrahimAngel Cid-Arregui
Nov 28, 2019·Expert Opinion on Biological Therapy·Mafalda G MoleirinhoCristina Peixoto
Nov 26, 2019·Human Gene Therapy Methods·Manuela GastBoris Mizaikoff
Jan 11, 2020·Critical Reviews in Biotechnology·Daniel LoewePeter Czermak
Oct 28, 2019·Frontiers in Microbiology·Michele Mutti, Lorenzo Corsini
Jul 17, 2020·Frontiers in Bioengineering and Biotechnology·Nils HillebrandtJürgen Hubbuch
Mar 19, 2019·Biotechnology and Bioengineering·Jordan TurnbullDaniel G Bracewell
Oct 23, 2020·Biotechnology Journal·Ana Sofia MoreiraCristina Peixoto
Aug 23, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pratik U JoshiCaryn L Heldt
Apr 26, 2021·Biotechnology Advances·Jorge JoãoAna M Azevedo
Apr 30, 2021·Biotechnology and Bioengineering·Sofia B CarvalhoRicardo J S Silva
Jul 14, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Seval Bilge-DagalpGaetano Donofrio
Aug 23, 2021·Advanced Drug Delivery Reviews·Simon StaubachBernd Giebel

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
size exclusion chromatography
ELISA
Electrophoresis
primary
ion-exchange chromatography

Software Mentioned

PAT

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Related Papers

Biological Chemistry
D H KrügerW H Gerlich
Bulletin de l'Académie nationale de médecine
P Nicolle
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
G V PopovG K Khristova
Biological Reviews of the Cambridge Philosophical Society
M DELBRUCK
© 2022 Meta ULC. All rights reserved