Downstream targets of GATA3 in the vestibular sensory organs of the inner ear.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
David M AlvaradoMichael Lovett

Abstract

Haploinsufficiency for the transcription factor GATA3 leads to hearing loss in humans. It is expressed throughout the auditory sensory epithelium (SE). In the vestibular organs, GATA3 is limited to the striola reversal zone of the utricle. Stereocilia orientation shifts 180 degrees at this region, which contains morphologically distinct type-I hair cells. The striola is conserved in all amniotes, its function is unknown, and GATA3 is the only known marker of the reversal zone. To identify downstream targets of GATA3 that might point to striolar function, we measured gene expression differences between striolar and extra-striolar SE. These were compared with profiles after GATA3 RNAi and GATA3 over-expression. We identified four genes (BMP2, FKHL18, LMO4, and MBNL2) that consistently varied with GATA3. Two of these (LMO4 and MBNL2) were shown to be direct targets of GATA3 by ChIP. Our results suggest that GATA3 impacts WNT signaling in this region of the sensory macula.

References

Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·H OsadaT H Rabbitts
Jun 29, 1995·Nature·D HenriqueD Ish-Horowicz
Jun 1, 1994·Nature Structural Biology·G C Pérez-AlvaradoM F Summers
Feb 21, 1998·Nucleic Acids Research·T HeinemeyerN A Kolchanov
Dec 31, 1997·The Journal of Comparative Neurology·A Lysakowski, J M Goldberg
Aug 10, 2000·Nature·H Van EschK Devriendt
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H KishikawaI C Ho
Jan 17, 2002·The Journal of Comparative Neurology·Grace Lawoko-KeraliMatthew Holley
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mats H HolmqvistW Frank An
Feb 28, 2002·Current Opinion in Neurobiology·Donna M Fekete, Doris K Wu
Mar 15, 2002·The Journal of Biological Chemistry·Cecile Lavenu-BombledIsabelle Max-Audit
Sep 6, 2002·Experimental Cell Research·Anna FalkJonas Frisén
Dec 26, 2002·Annual Review of Immunology·Susanne J SzaboLaurie H Glimcher
Jan 16, 2003·Gene·Bingyu Mao, Christof Niehrs
Aug 19, 2003·Genes & Development·Charles K KaufmanElaine Fuchs
Aug 30, 2003·The Journal of Biological Chemistry·Masami SakamotoRyoichiro Kageyama
Oct 31, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Georges RawadiSergio Roman-Roman
Jun 23, 2004·Neurobiology of Disease·Jacqueline van der WeesJ Hikke van Doorninck
Jul 10, 2004·Developmental Biology·Quianna BurtonDoris K Wu
Sep 10, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kenneth J RhodesJames S Trimmer
Sep 15, 2004·Brain Research. Molecular Brain Research·Hui XiongZhuohua Zhang
Oct 16, 2004·The Journal of Biological Chemistry·Irfan S KathiriyaOsamu Nakagawa
Nov 16, 2004·Experimental Cell Research·Zhengqing HuMats Ulfendahl
Nov 18, 2004·Immunological Reviews·Kerri A Mowen, Laurie H Glimcher
Feb 3, 2006·Development·Corina GuderThomas W Holstein
Mar 15, 2006·Differentiation; Research in Biological Diversity·Maya PascualRuben Artero
Apr 7, 2006·Gene Expression Patterns : GEP·Min DengLin Gan
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Frederic MorvanGeorges Rawadi
Jun 30, 2006·Mechanisms of Development·Kersti LilleväliMarjo Salminen
Nov 23, 2006·The Journal of Cell Biology·Cristina de Guzman StrongJulia A Segre
Aug 22, 2007·Molecular and Cellular Biology·Hirochika KitagawaLeonard P Freedman
Feb 24, 2010·Journal of the Association for Research in Otolaryngology : JARO·Mark E Warchol, Mireille Montcouquiol

❮ Previous
Next ❯

Citations

Aug 31, 2013·Journal of the Association for Research in Otolaryngology : JARO·Amber D Slowik, Olivia Bermingham-McDonogh
Jun 9, 2012·BMC Genomics·TuShun R PowersElba E Serrano
Apr 25, 2013·PloS One·Jeremy S Duncan, Bernd Fritzsch
Sep 26, 2015·Journal of Anatomy·Thomas Schimmang, Mark Maconochie
Jul 29, 2015·Scientific Reports·Shyan-Yuan Kao, Konstantina M Stankovic
Dec 4, 2019·Cell and Tissue Research·Lejo Johnson ChackoAnneliese Schrott-Fischer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.