PMID: 48779May 24, 1975

Doxantrazole, an antiallergic agent orally effective in man

J F BatchelorJ E Tateson


In-vivo studies have demonstrated antiallergic properties in doxantrazole when given orally to rats. These properties were confirmed in work with in-vitro preparations. No significant animal toxicity has been detected. 200 mg. given by mouth inhibited the immediate-type asthmatic response in volunteer patients challenged with specific antigen.


Jan 3, 1977·European Journal of Clinical Pharmacology·H Poppius, B Stenius
Oct 1, 1977·Agents and Actions·J AugsteinP Sheard
Apr 1, 1981·Agents and Actions·R G Alvarez, W Kazimierczak
Jun 1, 1976·Acta Allergologica·R PauwelsM Van der Straeten
Apr 3, 1976·British Medical Journal·J C Foreman, L G Garland
Jan 13, 1979·British Medical Journal·H R GribbinA E Tattersfield
Aug 2, 1975·British Medical Journal·S P HayduD T Hughes
Sep 1, 1976·Clinical Allergy·R PauwelsM Van der Straeten
May 1, 1978·Clinical Allergy·R PauwelsM Van der Straeten
May 1, 1978·Clinical Allergy·A MuittariT Veneskoski
May 1, 1982·Clinical and Experimental Dermatology·M P James
May 1, 1982·Clinical and Experimental Dermatology·A K Black
Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·I C CaldwellM Weatherall
Sep 1, 1976·Clinical Allergy·R PauwelsM Van der Straeten
May 1, 1987·British Journal of Pharmacology·J GoossensJ P Van Wauwe

Related Concepts

Drug Evaluation
Medicinal Plants Testing, Preclinical
Histamine Release

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.