PMID: 48779May 24, 1975

Doxantrazole, an antiallergic agent orally effective in man

Lancet
J F BatchelorJ E Tateson

Abstract

In-vivo studies have demonstrated antiallergic properties in doxantrazole when given orally to rats. These properties were confirmed in work with in-vitro preparations. No significant animal toxicity has been detected. 200 mg. given by mouth inhibited the immediate-type asthmatic response in volunteer patients challenged with specific antigen.

Citations

Jan 3, 1977·European Journal of Clinical Pharmacology·H Poppius, B Stenius
Oct 1, 1977·Agents and Actions·J AugsteinP Sheard
Apr 1, 1981·Agents and Actions·R G Alvarez, W Kazimierczak
Jun 1, 1976·Acta Allergologica·R PauwelsM Van der Straeten
Apr 3, 1976·British Medical Journal·J C Foreman, L G Garland
Jan 13, 1979·British Medical Journal·H R GribbinA E Tattersfield
Aug 2, 1975·British Medical Journal·S P HayduD T Hughes
Sep 1, 1976·Clinical Allergy·R PauwelsM Van der Straeten
May 1, 1978·Clinical Allergy·R PauwelsM Van der Straeten
May 1, 1978·Clinical Allergy·A MuittariT Veneskoski
May 1, 1982·Clinical and Experimental Dermatology·M P James
May 1, 1982·Clinical and Experimental Dermatology·A K Black
Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·I C CaldwellM Weatherall
Sep 1, 1976·Clinical Allergy·R PauwelsM Van der Straeten
May 1, 1987·British Journal of Pharmacology·J GoossensJ P Van Wauwe

Related Concepts

Asthma
Drug Evaluation
Medicinal Plants Testing, Preclinical
Histamine Release
Tetrazoles
Thioxanthenes

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