Doxazosin for the treatment of co-occurring PTSD and alcohol use disorder: Design and methodology of a randomized controlled trial in military veterans.

Contemporary Clinical Trials
Sudie E BackConsortium to Alleviate PTSD

Abstract

Posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) are two of the most common mental health disorders affecting civilians as well as military populations. If left untreated, individuals with co-occurring PTSD/AUD are at increased risk for developing other mental health problems (e.g., depression, anxiety), physical health problems, reduced resiliency and military readiness, and vocational and social impairment. Substantial gaps in the treatment of co-occurring PTSD/AUD exist and there is a critical need to develop more effective pharmacological treatments. The current study addresses this gap in the literature by testing the efficacy and safety of doxazosin, a long-acting and selective alpha-1 adrenergic antagonist, as compared to placebo in reducing PTSD and AUD severity among U.S. military veterans. Noradrenergic dysregulation has been implicated in the development and maintenance of PTSD and AUD, and pilot studies examining doxazosin in PTSD-only or AUD-only samples have shown promise. This is the first study, however, to evaluate doxazosin in a comorbid PTSD/AUD sample. This paper describes the rationale, design and methodology of a randomized, double-blind, placebo-controlled trial of doxazosin (16 mg/day...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jan 1, 1992·Journal of Substance Abuse Treatment·A T McLellanM Argeriou
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Apr 19, 2000·JAMA : the Journal of the American Medical Association·K BradyG M Farfel
Mar 23, 2002·Journal of Clinical Psychopharmacology·Joseph ZoharCarol Austin
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·R S KirbyP Abrams
Feb 4, 2003·The American Journal of Psychiatry·Murray A RaskindMiles M McFall
Apr 18, 2003·Journal of Consulting and Clinical Psychology·Paige OuimetteJohn W Finney
Apr 25, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ashwin A PatkarCharles A Marsden
Oct 24, 2003·Alcoholism, Clinical and Experimental Research·Mats BerglundAgneta Ojehagen
Feb 12, 2004·Journal of Psychopharmacology·Jonathan ChickUNKNOWN Plinius Maior Society
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Kathleen T BradyKit Simpson
Jun 17, 2005·The New England Journal of Medicine·Ronald C KesslerAlan M Zaslavsky
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christophe LanteriJean-Pol Tassin
Jun 20, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rajita SinhaKristen M Siedlarz
Oct 24, 2008·Alcoholism, Clinical and Experimental Research·Tracy L SimpsonMurray Raskind
Jan 16, 2010·Journal of Clinical Psychopharmacology·Joop De JongJudith Haffmans
Jun 10, 2010·Journal of Psychopharmacology·N J KalkA R Lingford-Hughes
Apr 12, 2011·The American Journal on Addictions·Ismene L PetrakisRani Desai
Jul 30, 2011·The International Journal of Neuropsychopharmacology·Jonathan C Ipser, Dan J Stein
Sep 17, 2011·Alcoholism, Clinical and Experimental Research·Helen C FoxRajita Sinha
Nov 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ismene L PetrakisJohn H Krystal
May 10, 2012·Social Cognitive and Affective Neuroscience·Jill X O'ReillyHeidi Johansen-Berg
Jul 5, 2012·Alcoholism, Clinical and Experimental Research·Meghan L O'NeilDennis D Rasmussen
Aug 18, 2012·Journal of Substance Abuse Treatment·John S CacciolaJames R McKay
Jul 13, 2013·The American Journal of Psychiatry·Murray A RaskindElaine R Peskind
Aug 9, 2013·JAMA : the Journal of the American Medical Association·Edna B FoaJoseph Volpicelli
Sep 17, 2013·Addictive Behaviors·Mehmet SofuogluIsmene Petrakis
Jan 9, 2014·The American Journal of Psychiatry·Eric HermesRobert Rosenheck

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Citations

Feb 20, 2020·Military Medicine·Mulugu V Brahmajothi, Mohamed B Abou-Donia
Nov 26, 2019·Current Treatment Options in Psychiatry·Julianne C Flanagan, Jennifer M Mitchell
Sep 9, 2021·Journal of Neuroscience Research·Miranda C StaplesChitra D Mandyam

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