Abstract
Plasmablastic lymphoma (PBL) is an aggressive variant of diffuse large B-cell lymphoma. We sought to assess the treatment outcomes after combined-modality therapy for early-stage PBL. We retrospectively reviewed the outcomes of 10 consecutive patients diagnosed with stage I-II PBL from February 2001 to December 2013 at a single institution. The baseline clinical characteristics, treatment modalities, overall outcomes, and treatment-related toxicity were assessed. The median age at diagnosis was 50.5 years. All patients had extranodal disease; 2 were positive for human immunodeficiency virus. Seven patients received hyper-CVAD (cyclophosphamide, vincristine, doxorubicin, dexamethasone)-based chemotherapy, 2 received CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and 1 received dose-adjusted EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin). Radiotherapy (RT) was administered after a complete response to chemotherapy in 7 patients and a partial response in 1 patient. At a median follow-up period of 42 months, the estimated 2-year progression-free and overall survival rates were 90% and 100%, respectively. PBL can be successfully treated with aggressive chemotherapy followed by RT. The treat...Continue Reading
References
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Apr 4, 2002·Blood·Wyndham H WilsonFrank Balis
Mar 18, 2008·Journal of the American Academy of Dermatology·Anokhi JambusariaClifford Perlis
Apr 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wyndham H WilsonJohn E Janik
Aug 30, 2008·American Journal of Hematology·Jorge CastilloBruce J Dezube
Oct 23, 2008·Oral Diseases·P Rafaniello RavieleE Maiorano
Sep 19, 2009·American Journal of Clinical Pathology·Agata M BoguszWeina Chen
Nov 17, 2009·Journal of Hematology & Oncology·Chung-Che ChangChing-Ching Lau
Aug 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jack PhanBouthaina Shbib Dabaja
Oct 6, 2010·Leukemia & Lymphoma·Jorge J CastilloJames N Butera
Oct 22, 2010·The American Journal of Surgical Pathology·Alexandra ValeraElías Campo
May 18, 2011·Clinical Lymphoma, Myeloma & Leukemia·Jorge J CastilloJames N Butera
Jan 12, 2012·Transplantation·Heiner ZimmermannRalf U Trappe
Aug 1, 2013·Current Hematologic Malignancy Reports·Belinda A Campbell
Sep 26, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerhard HeldMichael Pfreundschuh
Oct 15, 2013·British Journal of Haematology·Yasuhiro OkiLuis Fayad
Dec 18, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alexandar TzankovKen H Young
Apr 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Tim IllidgeUNKNOWN International Lymphoma Radiation Oncology Group
Jun 21, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Monzr M Al-MalkiAlessandro Re
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Feb 20, 2015·Oncology Reports·Min LiuLihua Dong
Citations
Mar 2, 2016·Annals of Hematology·Keichiro MiharaShinichi Suehiro
Sep 12, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C Demoor-GoldschmidtM A Mahé
Jul 12, 2017·PloS One·Shuyan CaoYuxue Wang
Feb 9, 2019·American Journal of Hematology·Nivedita AroraNavid Sadeghi
Nov 2, 2017·Case Reports in Hematology·Hind RafeiGeraldine P Schechter
Jan 10, 2021·Clinical Lymphoma, Myeloma & Leukemia·Nafie F MakadyKyrillus S Shohdy
Jun 7, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Felipe Paiva FonsecaWillie F P van Heerden