PMID: 589261Dec 3, 1977

Doxorubicin cardiotoxicity: possible role of digoxin in its prevention

British Medical Journal
D Guthrie, A L Gibson

Abstract

Twenty-nine patients with gynaecological cancers who received over 400 mg of doxorubicin were monitored electrocardiographically to determine whether cardiac glycosides countered the adverse effects of high total doses of doxorubicin. Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin. One other patient on digoxin stopped taking it and developed cardiomyopathy. One patient on ouabain also developed cardiomyopathy. So far nine patients on digoxin have received between 550 and 1000 mg/m2 of doxorubicin without ill effect. Cardiac glycosides are thought to prevent doxorubicin cardiomyopathy by competitively inhibiting doxorubicin at its receptor sites, but ouabain has a much shorter half life than doxorubicin and its metabolites and so is less effective than digoxin.

References

Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb

Citations

Jan 1, 1988·Archives of Gynecology and Obstetrics·L C FuithH Hetzel
Jan 1, 1982·European Journal of Cancer & Clinical Oncology·B HöflingH D Bolte
Feb 1, 1981·Toxicology Letters·A PourJ Modrak
Jun 2, 2016·The Journal of Pharmacology and Experimental Therapeutics·Shahira M EzzatThomas Simmet
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Apr 3, 2020·Chemical Biology & Drug Design·Sandeep RanaAmarnath Natarajan
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Related Concepts

Mapluxin
Ribodoxo
Electrocardiographic Recorders
Genital Neoplasms, Female
Heart Diseases
Ouabain

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