DOXORUBICIN-INDUSED DISTURBANCES OF CARDIOMYOCYTE CONTRACTILE ACTIVITY

Fiziolohichnyĭ zhurnal
O O LinnikI M Mankovska

Abstract

The aim of our study was to find out the mechanisms of cardiomyocyte contractile activity disturbances under the influence of anthracycline antibiotics and curcumin correction capabilities, to clarify the role of the mitochondrial membrane potential changes in cardiomyocyte contractile activity. It was investigated disturbances of contractile activity of the rat neonatal cardiomyocytes under the influence of anthracycline antibiotics (doxorubicin), and the possibility of correcting these violations using antioxidant curcumin. In addition, there was researched the role of mitochondrial membrane potential changes in reducing contractile activity of the cardiomyocytes. We established that doxorubicin causes significant changes in all reduction parameters compared to control: increased frequency of spontaneous contractions, violation of rhythm, lower amplitude and the shortening %, increase in the maximum speed of contraction and relaxation without changes in duration of these processes. Compatible incubation with doxorubicin and curcumin caused a consid- erable decrease of the incidence of spontaneous emission (3 times), restored their rhythm, increasing the amplitude of 2 times and the shortening % (8,15 ± 0,37), rising the maxim...Continue Reading

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Citations

Jun 26, 2021·Current Problems in Cardiology·Ashot AvagimyanNizal Sarrafzadegan

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