Doxorubicin-loaded biodegradable self-assembly zein nanoparticle and its anti-cancer effect: Preparation, in vitro evaluation, and cellular uptake

Colloids and Surfaces. B, Biointerfaces
Fangyuan DongYi Wang

Abstract

Cancer is one top leading cause of the deaths worldwide. Various anticancer drugs, which can effectively kill cancer cells, have been developed in the last decade. However, the problem is still about the low therapeutic index of the drugs, which means that the effective dose of drugs will cause cytotoxicity to normal cells. A strategy based on drug nano-encapsulation is applied to achieve an effective anti-cancer therapy. In this study, we use zein, which is an amphiphilic protein, to make the anti-cancer drug nano-encapsulation. Doxorubicin (DOX), a popular anti-cancer drug, is selected as the core drug. The results show that DOX could be successfully encapsulated into zein to form spherical nanoparticles. The encapsulation efficiency and loading efficiency could reach as high as 90.06% and 15.01 mg/g, respectively. The cumulative release result showed a desired pH-responsible release behavior: DOX could be released faster in acidic buffer solutions (pH 5.0 and 6.5) than neutral one (pH 7.4). The effects of the nano-encapsulation on the anti-proliferation of HeLa cells were also examined. It indicated that, compared with free DOX, the DOX-loaded zein nanoparticles (DOX-zein-NPs) had a better effect on cancer cell killing at lo...Continue Reading

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Oct 25, 2016·International Journal of Pharmaceutics·Yong ZhangWei Kong
Oct 12, 2016·Chemical & Pharmaceutical Bulletin·Shiro NakaiTakashi Michida
Mar 2, 2017·Journal of Agricultural and Food Chemistry·Chun LiuXiaoquan Yang
Jul 19, 2018·Journal of Food Science·Xiao FengHongshun Yang
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Jan 19, 2020·Pharmaceutics·Silvia VociDonato Cosco
Sep 2, 2020·Advanced Drug Delivery Reviews·Anastasia VarankoAshutosh Chilkoti
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Sep 10, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Xiao YuJichao Wang
Feb 8, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Heting HouYi Wang

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