PMID: 12766562May 27, 2003Paper

Doxorubicin-resistant, MRP1-expressing U-1285 cells are sensitive to idarubicin

Therapeutic Drug Monitoring
Kerstin Jönsson-VidesäterC Paul

Abstract

A doxorubicin-resistant subline (U-1285dox(900)) was derived from the human small cell lung carcinoma cell line U-1285. U-1285dox(900) was exposed to a wide range of anticancer agents to determine its resistance profile. In contrast to U-1285 cells, the resistant subline U-1285dox(900) expressed elevated MRP1 mRNA detected by reversed transcriptase-polymerase chain reaction (RT-PCR) and MRP1 protein analyzed with Western blot. Neither MDR1 mRNA nor P-glycoprotein could be detected in the parental cell line or resistant subline. U-1285dox(900) exhibited high resistance to doxorubicin, epirubicin, daunorubicin, and vincristine, an intermediate resistance to mitoxantrone, and a low resistance to etoposide. A collateral sensitivity to cytosine arabinoside, chlorodeoxyadenosine, and melphalan was observed. The resistance could be reversed by buthionine-sulphoximine and verapamil for all tested drugs. Compared with daunorubicin, resistance to idarubicin was very low, 14-fold and 2.6-fold, respectively. This was associated with a higher accumulation due to a slower transport of idarubicin out of U-1285dox(900) cells.

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Citations

Mar 24, 2004·Biochemical Pharmacology·Kerstin Jönsson-VidesäterMikael Björnstedt
Aug 16, 2011·Pharmacology & Therapeutics·Rene KizekMarie Stiborova
Sep 19, 2009·Trends in Pharmacological Sciences·Matthew D HallMichael M Gottesman
Aug 12, 2009·Biochemical Pharmacology·Valentina GandinCristina Marzano
Oct 27, 2004·Peptides·Linda Björkhem-BergmanMats Andersson
Jul 16, 2008·Biochimica Et Biophysica Acta·László SeresLászló Homolya
Aug 18, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Andreia ValentePetra Heffeter

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