Doxorubicin/gold nanoparticles coated with liposomes for chemo-photothermal synergetic antitumor therapy

Nanotechnology
Shanshan XingDawei Gao

Abstract

Hybrid liposome/metal nanoparticles are promising candidate drug-carriers for therapy of various diseases due to their unique photothermal effect. In this study, self-crystallized gold nanoparticles (Au NPs) and doxorubicin (DOX) were co-encapsulated within liposomes (Au/DOX-Lips) by thin film hydration and gel separation technology. The surface plasmon resonance bands of drug-carriers were controllable in the near-infrared (NIR) zone. When the complex liposome/metallic hybrids were irradiated by NIR light, they displayed higher endocytosis efficiency following the fracture of liposomal membranes and the release of Au NPs. Then, the Au NPs penetrated further into deeper tumor tissue to accomplish photothermal treatment. The Au/DOX-Lips showed an excellent antitumor effect, whose inhibition rate for tumor cells was up to 78.28%. In experiments on mice bearing tumors, the Au/DOX-Lips treated mice exhibited superior tumor suppression. This novel drug system provides huge potential for biomedical application.

References

May 29, 2012·ACS Nano·Gregory Von WhiteChristopher L Kitchens
Aug 28, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Babak Y MoghadamJonathan D Posner
Oct 12, 2012·The Journal of Antimicrobial Chemotherapy·Ernest A AzzopardiDavid W Thomas
Oct 18, 2012·Cancer Research·Shuaidong HuoXing-Jie Liang
Dec 19, 2013·Chemistry, an Asian Journal·Wei CaoHuaping Xu
May 23, 2015·Biotechnology and Bioengineering·Nick Frazier, Hamidreza Ghandehari
Jul 20, 2016·Journal of Nanoscience and Nanotechnology·Kil Ju Na, Gye-Choon Park
Dec 29, 2016·Science Advances·Jin-Ho LeeTaewook Kang
Jan 7, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Sarah KubeAgnes Csiszár
Feb 2, 2017·Molecular Pharmaceutics·Han CuiSi-Yuan Zhou
Apr 2, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Yanping LiuDawei Gao
Mar 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Meili WangDawei Gao

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Citations

Oct 4, 2018·Current Gene Therapy·Cen YanYing-Mei Feng
Jul 30, 2020·Pharmaceutics·Moon Sung KangDong-Wook Han
Jan 31, 2021·Journal of Pharmaceutical Sciences·Sudtirak WongkhieoMattaka Khongkow
Jan 27, 2021·ACS Nano·Joshua SeabergPriyabrata Mukherjee
Jun 22, 2021·ACS Pharmacology & Translational Science·Nour AlSawaftahGhaleb A Husseini
Jul 29, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Leonardo BianchiPaola Saccomandi
Jul 8, 2019·ACS Biomaterials Science & Engineering·Shuxian ZhaoDawei Gao

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