Doxycycline-chloroquine vs. doxycycline-placebo for malaria prophylaxis in nonimmune soldiers: a double-blind randomized field trial in sub-Saharan Africa

Transactions of the Royal Society of Tropical Medicine and Hygiene
Rémy MichelJean-Etienne Touze

Abstract

Failures of malaria chemoprophylaxis have been related to a lack of compliance with doxycycline due to its short elimination half-life. Adding a molecule with a long half-life to doxycycline could be useful to take over from this drug in case of occasional missed doses. A double-blind, placebo-controlled randomized field trial was designed to compare the tolerability of a doxycycline-chloroquine combination vs. doxycycline as malaria prophylaxis among French soldiers deployed in Africa. Data from 936 volunteers were analyzed. In both groups, the proportion of volunteers who reported at least one adverse effect was about 57%. Tolerability was similar in the groups except for a higher proportion of nausea or vomiting in the doxycycline-chloroquine group. The reported compliance rate was 86.6% and was similar in the two groups. Eight Plasmodium falciparum malaria cases were diagnosed in the doxycycline group and seven in the doxycycline-chloroquine group. The efficacy of the two chemoprophylaxis regimens was similar. Our study was the first randomized field trial to assess a doxycycline-chloroquine combination as malaria prophylaxis and showed no significant decrease of overall tolerability of the combination compared with doxycyc...Continue Reading

References

Jun 1, 1994·The American Journal of Tropical Medicine and Hygiene·S LooareesuwanD E Kyle
Jan 1, 1996·The American Journal of Medicine·M R WallaceJ P Burans
Aug 1, 1997·Scandinavian Journal of Clinical and Laboratory Investigation·A MäkeläT Schröder
May 23, 1998·The American Journal of Tropical Medicine and Hygiene·J PhilippsP G Kremsner
Aug 5, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SotoJ Berman
Sep 14, 1999·The American Journal of Gastroenterology·I A ElandB H Stricker
Apr 13, 2000·The American Journal of Tropical Medicine and Hygiene·B PradinesD Parzy
May 29, 2000·Pancreas·T Otani, A Matsukura
Sep 19, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·B AxisaM M Thompson
Oct 23, 2002·Tropical Medicine & International Health : TM & IH·Frédéric PagèsDominique Baudon
Mar 22, 2003·BMJ : British Medical Journal·J Lochhead, J S Elston
Jun 7, 2003·The Journal of Infectious Diseases·James G KublinChristopher V Plowe
Sep 25, 2003·The Journal of Experimental Biology·Christopher V Plowe
Jun 24, 2004·Neurology·D I FriedmanY Goldhammer
Nov 10, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Miriam K Laufer, Christopher V Plowe

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Citations

Jul 24, 2014·Travel Medicine and Infectious Disease·R MichelR Migliani
Apr 15, 2016·Expert Opinion on Drug Safety·Bryan Grabias, Sanjai Kumar
Jun 15, 2010·Travel Medicine and Infectious Disease·Roberto RomiGiancarlo Majori
Jul 1, 2015·The American Journal of Tropical Medicine and Hygiene·David L SaundersAlan J Magill
Aug 4, 2018·Canadian Journal of Physiology and Pharmacology·Vinoth RajendranPrahlad C Ghosh
Nov 26, 2010·Scandinavian Journal of Infectious Diseases·Anne-Pauline BellangerBruno Hoen
Feb 9, 2017·Malaria Journal·Tânia do Socorro Souza ChavesMarta Heloisa Lopes
Nov 19, 2020·Patient Preference and Adherence·Chaturaka RodrigoSumadhya Deepika Fernando
Apr 16, 2020·International Journal of Antimicrobial Agents·Mathieu GendrotBruno Pradines
Sep 12, 2020·Travel Medicine and Infectious Disease·Mathieu GendrotBruno Pradines

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