Doxycycline clearance of experimentally induced chronic Ehrlichia canis infection in dogs

Journal of Veterinary Internal Medicine
S M EddlestoneE B Breitschwerdt

Abstract

Ineffective clearance of Ehrlichia canis after doxycycline administration has been reported despite the fact that the recommended treatment for canine ehrlichiosis is doxycycline. The effectiveness of doxycycline in clearing E canis infection from the blood and tissues of dogs requires additional evaluation. Doxycycline (5 mg/kg PO q12h), administered for 4 weeks, will eliminate E canis infection from the blood and tissues of experimentally infected dogs. Fifteen Walker hound-mixed breed dogs were inoculated subcutaneously with E canis-infected canine histiocytic cells 4 months before doxycycline treatment. Four dogs were treated with doxycycline (5 mg/kg PO q12h for 3 weeks), 5 dogs were treated with doxycycline at the same dosage for 4 weeks, and 5 control dogs were not treated. Dexamethasone (0.4 mg/kg i.v.) was given after treatment to precipitate recrudescence of any remaining E canis organisms. Platelet counts, anti-E canis immunofluorescent antibodies, and polymerase chain reaction (PCR) detection of E canis deoxyribonucleic acid (DNA) in blood and tissues were evaluated. E canis DNA was not detected in the blood and tissues of doxycycline-treated dogs after treatment. Platelet counts were within reference intervals, and...Continue Reading

References

Oct 29, 1997·The Journal of Veterinary Medical Science·W L ChangM J Pan
Jun 5, 1999·Journal of Veterinary Internal Medicine·J R Frank, E B Breitschwerdt
Mar 10, 2004·Journal of the American Animal Hospital Association·Edward B BreitschwerdtMichael D Willard
Sep 8, 2006·Journal of Veterinary Internal Medicine·S M EddlestoneE B Breitschwerdt

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Citations

May 5, 2009·Journal of the American Animal Hospital Association·Barbara C HegartyEdward Breitschwerdt
Mar 13, 2014·Journal of Veterinary Pharmacology and Therapeutics·K KuKanichE Heinrich
Jan 28, 2015·Emerging Infectious Diseases·Victoria L O'NionEdward B Breitschwerdt
Mar 12, 2013·The Journal of Antimicrobial Chemotherapy·Konstantina TheodorouShimon Harrus
Oct 1, 2014·The American Journal of Tropical Medicine and Hygiene·Cruz M Arraga-AlvaradoEdward B Breitschwerdt
Mar 29, 2011·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Joice Lara Maia FariaMirela Tinucci-Costa
Jun 5, 2015·Journal of Veterinary Science·Jusun HwangMyung-Sun Chun
May 29, 2015·Journal of the South African Veterinary Association·Josephus J FourieOckert J Botha
Apr 14, 2010·Journal of Veterinary Internal Medicine·M E MylonakisA F Koutinas
May 28, 2009·Vector Borne and Zoonotic Diseases·Pedro Paulo V P DinizEdward B Breitschwerdt
Jun 26, 2015·Medical and Veterinary Entomology·A M PalomarJ A Oteo
Oct 26, 2011·Vector Borne and Zoonotic Diseases·Tania AyllónAngel Sainz
Jul 24, 2013·Journal of Veterinary Internal Medicine·B A QurolloE B Breitschwerdt

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