Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains.

Antimicrobial Agents and Chemotherapy
E B BreitschwerdtS I Hancock

Abstract

Dogs were experimentally inoculated with Ehrlichia canis Florida to assess the efficacy of doxycycline hyclate for the treatment of acute ehrlichiosis. Treatment with doxycycline eliminated infection in eight of eight dogs. Untreated infected control dogs appeared to eliminate the infection or, alternatively, suppress the degree of ehrlichiemia to a level not detectable by tissue culture isolation or PCR or by transfusion of blood into recipient dogs. Prior infection did not infer protection against homologous (strain Florida) or heterologous (strain NCSU Jake) strains of E. canis. We conclude that doxycycline hyclate is an effective treatment for acute E. canis infection; however, these results may not be applicable to chronic infections in nature. Spontaneous resolution of infection, induced by the dog's innate immune response, provides evidence that an E. canis vaccine, once developed, might potentially confer protective immunity against the organism.

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Citations

Apr 22, 2003·Infection and Immunity·Jere W McBrideDavid H Walker
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allison M LiddellGregory A Storch
Oct 6, 2010·Antimicrobial Agents and Chemotherapy·Jennifer C McClureRoger W Stich
Jul 4, 2007·Antimicrobial Agents and Chemotherapy·John J SchaeferR W Stich
Mar 12, 2013·The Journal of Antimicrobial Chemotherapy·Konstantina TheodorouShimon Harrus
May 5, 2009·Journal of the American Animal Hospital Association·Barbara C HegartyEdward Breitschwerdt
Dec 24, 2003·Journal of the American Veterinary Medical Association·Jennifer H McQuistonWilliam L Nicholson
Sep 9, 2010·Expert Review of Vaccines·Jere W McBride, David H Walker
Feb 5, 2015·Parasites & Vectors·Ángel SainzLaia Solano-Gallego
Jul 13, 2000·Veterinary Immunology and Immunopathology·B L PappalardoE B Breitschwerdt
Jun 28, 2001·Journal of Clinical Microbiology·A R AllemanM Bélanger
Jul 16, 1999·Journal of Clinical Microbiology·S K KordickJ N MacCormack
Aug 31, 2002·Journal of Clinical Microbiology·Myriam BélangerA Rick Alleman

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