Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis

The Cochrane Database of Systematic Reviews
Ayokunle T AbegundeNkem J Okafor

Abstract

Onchocerciasis, also known as "river blindness," is a parasitic disease that is caused by infection from the filarial nematode (roundworm), Onchocerca volvulus. Nematodes are transmitted from person to person by blackflies of the Simulium genus, which usually breed in fast flowing streams and rivers. The disease is the second leading infectious cause of blindness in endemic areas.Ivermectin (a microfilaricide) is widely distributed to endemic populations for prevention and treatment of onchocerciasis. Doxycycline, an antibiotic, targets Wolbachia organisms that are crucial to the survival of adult onchocerca (macrofilaricide). Combined treatment with both drugs is believed to cause direct microfilarial death by ivermectin and indirect macrofilarial death by doxycycline. Long-term reduction in the numbers of microfilaria in the skin and eyes and in the numbers of adult worms in the body has the potential to reduce the transmission and occurrence of onchocercal eye disease. The primary aim of this review was to assess the effectiveness of doxycycline plus ivermectin versus ivermectin alone for prevention and treatment of onchocerciasis. The secondary aim was to assess the effectiveness of doxycycline plus ivermectin versus iverme...Continue Reading

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Citations

Feb 25, 2017·Travel Medicine and Infectious Disease·Spinello AntinoriAnna Lisa Ridolfo
Sep 10, 2019·The Indian Journal of Medical Research·Wan Aliaa Wan SulaimanHamidon Basri
Aug 5, 2020·The American Journal of Tropical Medicine and Hygiene·Marcos de AlmeidaAlexandre J da Silva
Feb 25, 2020·ACS Infectious Diseases·Natalie A Hawryluk

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