DPP4 Inhibitors in the Management of Hospitalized Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Advances in Therapy
Soghra RabizadehManouchehr Nakhjavani

Abstract

We studied the effects of dipeptidyl peptidase 4 (DPP4) inhibitors on glycemic control in non-critically ill patients admitted to hospital. We searched MEDLINE and EMBASE for published studies in English up to July 2019. We included randomized clinical trials (RCTs) that compared DPP4 inhibitors plus insulin supplementation versus basal-bolus insulin regimen in the management of hyperglycemia non-critically ill patients with type 2 diabetes admitted to hospital. Mean difference (MD), relative risk (RR), and 95% confidence intervals (CI) were generated to interpret the data. Of 401 papers, four RCTs including 648 participants met inclusion criteria. There was no significant difference in mean daily blood glucose level between the two groups (MD 4.63; 95% CI = - 1.57, 10.83; p = 0.14) (I2 = 14%, p = 0.32). Total insulin dose per day was lower in patients receiving DPP4 inhibitors (MD - 14.27; CI = - 22.47, - 6.07; p = 0.001) (I2 = 92%, p = 0.001). Also, the number of insulin injection was significantly lower in patients receiving DPP4 inhibitors (MD - 0.79; CI = - 1.01, - 0.57; p = 0.001) (I2 = 0%, p = 0.68). The rate of hypoglycemia was not significantly different between the two groups (RR 0.60, CI = 0.34, 1.074; p = 0.08) (I2 ...Continue Reading

References

Apr 7, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·J J PomposelliB R Bistrian
Sep 19, 2001·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Guillermo E UmpierrezAbbas E Kitabchi
Oct 16, 2003·JAMA : the Journal of the American Medical Association·Simon J FinneyTimothy W Evans
Jun 15, 2007·Current Medical Research and Opinion·Markolf HanefeldUNKNOWN Sitagliptin Study 014 Investigators
Aug 30, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Renee E AmoriDeeb N Salem
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 15, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Nancy A Thornberry, Baptist Gallwitz
Nov 18, 2016·The Journal of Clinical Endocrinology and Metabolism·Amit AkirovIlan Shimon
Apr 14, 2017·BMJ Open Diabetes Research & Care·Rajesh GargShreya Bhandari
Aug 18, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Fernando Gomez-PeraltaGuillermo E Umpierrez
Sep 27, 2018·Journal of Diabetes and Its Complications·Maya FayfmanGuillermo E Umpierrez
Nov 13, 2018·JAMA : the Journal of the American Medical Association·Julio RosenstockUNKNOWN CARMELINA Investigators
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Sep 20, 2019·JAMA : the Journal of the American Medical Association·Julio RosenstockUNKNOWN CAROLINA Investigators

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