DpsA protects the human pathogen Burkholderia pseudomallei against organic hydroperoxide

Archives of Microbiology
Suvit LoprasertSkorn Mongkolsuk

Abstract

The human pathogen, Burkholderia pseudomalle, is able to survive and multiply in hostile environments such as within macrophages. In an attempt to understand its strategy to cope with oxidative stress, the physiological role and gene regulation of a nonspecific DNA-binding protein (DpsA) was investigated. Expression of dpsA increases in response to oxidative stress through increased transcription from the upstream katG (catalase-peroxidase) promoter, which is OxyR dependent. dpsA is also transcribed from its own promoter, which is activated by osmotic stress in an OxyR-independent manner. DpsA-deficient mutants are hypersensitive to tert-butyl hydroperoxide, while overexpression of DpsA leads to increased resistance to organic oxidants. B. pseudomallei DpsA can also protect Escherichia coli against organic hydroperoxide toxicity. The mechanism of DpsA-mediated resistance to organic hydroperoxides was shown to differ from that of alkyl hydroperoxide reductase.

References

Oct 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·E SteersC B Anfinsen
Jun 23, 1984·Lancet·B Halliwell, J M Gutteridge
Nov 7, 1995·Gene·K S Reece, G J Phillips
Jan 1, 1994·Methods in Enzymology·G Storz, M B Toledano
Jun 1, 1997·Journal of Bacteriology·K P FrancisM P Gallagher
Aug 1, 1997·Journal of Bacteriology·A Martinez, R Kolter
Jul 14, 1999·Nature·S G WolfA Minsky
Aug 31, 2000·Applied and Environmental Microbiology·S H ChoiC W Kaspar

❮ Previous
Next ❯

Citations

May 4, 2011·Antimicrobial Agents and Chemotherapy·Mohamad A HamadMartin I Voskuil
Feb 28, 2007·Infection and Immunity·Karen E Keith, Miguel A Valvano
Dec 5, 2006·Journal of Bacteriology·Alistair HarrisonRobert S Munson
Jul 25, 2012·BMC Genomics·Sylvia ChiengSheila Nathan
Feb 24, 2016·Biofouling·Michela Gambino, Francesca Cappitelli
Jun 5, 2007·Molecular Microbiology·Sandy M S WongBrian J Akerley
Feb 16, 2006·Environmental Microbiology·Leonid KurbatovLothar Petruschka
Oct 15, 2014·Expert Review of Anti-infective Therapy·Joshua K StoneMary N Burtnick
Dec 13, 2006·Microbiology·Putthapoom LumjiaktaseMongkol Kunakorn
May 10, 2019·Frontiers in Cellular and Infection Microbiology·Maribasappa KarchedSirkka Asikainen
Feb 2, 2018·Nature Reviews. Disease Primers·W Joost WiersingaDirek Limmathurotsakul
Jun 18, 2021·ACS Infectious Diseases·Supaksorn ChattagulRasana W Sermswan
Mar 3, 2012·Archives of Biochemistry and Biophysics·Sarah M Chiang, Herb E Schellhorn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.