DQueST: dynamic questionnaire for search of clinical trials.

Journal of the American Medical Informatics Association : JAMIA
Cong LiuChunhua Weng

Abstract

Information overload remains a challenge for patients seeking clinical trials. We present a novel system (DQueST) that reduces information overload for trial seekers using dynamic questionnaires. DQueST first performs information extraction and criteria library curation. DQueST transforms criteria narratives in the ClinicalTrials.gov repository into a structured format, normalizes clinical entities using standard concepts, clusters related criteria, and stores the resulting curated library. DQueST then implements a real-time dynamic question generation algorithm. During user interaction, the initial search is similar to a standard search engine, and then DQueST performs real-time dynamic question generation to select criteria from the library 1 at a time by maximizing its relevance score that reflects its ability to rule out ineligible trials. DQueST dynamically updates the remaining trial set by removing ineligible trials based on user responses to corresponding questions. The process iterates until users decide to stop and begin manually reviewing the remaining trials. In simulation experiments initiated by 10 diseases, DQueST reduced information overload by filtering out 60%-80% of initial trials after 50 questions. Reviewin...Continue Reading

References

Mar 1, 1994·Journal of the American Medical Informatics Association : JAMIA·C FriedmanS B Johnson
Jul 19, 2002·Journal of Biomedical Informatics·W W ChapmanB G Buchanan
Dec 19, 2003·Nucleic Acids Research·Olivier Bodenreider
Feb 24, 2009·Epidemiology·Kenneth J RothmanElizabeth E Hatch
Sep 1, 2009·Journal of the American Medical Informatics Association : JAMIA·Samir R ThadaniDavid Wajngurt
Dec 26, 2009·Journal of Biomedical Informatics·Chunhua WengRachel Richesson
Sep 8, 2010·Journal of the American Medical Informatics Association : JAMIA·Guergana K SavovaChristopher G Chute
Sep 21, 2010·Journal of Biomedical Informatics·Samson W TuIda Sim
Mar 4, 2011·The New England Journal of Medicine·Deborah A ZarinNicholas C Ide
Aug 3, 2011·Journal of the American Medical Informatics Association : JAMIA·Chunhua WengStephen B Johnson
Nov 15, 2012·Journal of Biomedical Informatics·Jihad S ObeidPaul A Harris
Aug 7, 2013·Journal of Biomedical Informatics·Riccardo MiottoChunhua Weng
May 28, 2015·Journal of Biomedical Informatics·Krystyna MilianJohn Paulissen
Oct 16, 2015·Nature·Andrew V BiankinSimon J Hollingsworth
Mar 5, 2016·Methods of Information in Medicine·Tianyong HaoChunhua Weng
Apr 6, 2017·Journal of the American Medical Informatics Association : JAMIA·Tian KangChunhua Weng

❮ Previous
Next ❯

Citations

Sep 27, 2019·Nature·Marcus Woo
Nov 21, 2020·Journal of the American Medical Informatics Association : JAMIA·Yingcheng SunChunhua Weng
Apr 5, 2021·Journal of Biomedical Informatics·Hao LiuChunhua Weng
Dec 8, 2021·Emerging Topics in Life Sciences·Jia Zeng, Md Abu Shufean

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01152203
NCT00948766
NCT00477659
NCT02958670
NCT00814697
NCT02968719
NCT00878059
NCT00297414

Software Mentioned

eTACTS
Lucene Java library
Apache
Criteria2Query
EliIE
MetaMap
SymptomMatcher
Research Electronic Data Capture application ( REDCap )
MedLEE
OMOP CDM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.