Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.

Current Opinion in Cell Biology
Norman PavelkaRong Li

Abstract

When cells in our body change their genome and develop into cancer, we blame it on genome instability. When novel species conquer inhospitable environments, we credit it to genome evolution. From a cellular perspective, however, both processes are outcomes of the same fundamental biological properties-genome and pathway plasticity and the natural selection of cells that escape death and acquire growth advantages. Unraveling the consequences of genome plasticity at a cellular level is not only central to the understanding of species evolution but also crucial to deciphering important cell biological problems, such as how cancer cells emerge and how pathogens develop drug resistance. Aside from the well-known role of DNA sequence mutations, recent evidence suggests that changes in DNA copy numbers in the form of segmental or whole-chromosome aneuploidy can bring about large phenotypic variation. Although usually detrimental under conditions suitable for normal proliferation of euploid cells, aneuploidization may be a frequently occurring genetic change that enables pathogens or cancer cells to escape physiological or pharmacological roadblocks.

References

Oct 1, 1976·Science·P C Nowell
Sep 7, 1987·Journal of Theoretical Biology·S Kauffman, S Levin
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jul 11, 2000·Nature Genetics·T R HughesM J Marton
Feb 24, 2001·Journal of the National Cancer Institute·T Webb
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·P DuesbergR Hehlmann
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·S K RehenJ Chun
Nov 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Maitreya J DunhamDavid Botstein
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stevens K RehenJerold Chun
Jul 22, 2006·Science·Anna SelmeckiJudith Berman
Oct 19, 2006·Current Opinion in Cell Biology·Beth A A Weaver, Don W Cleveland
Nov 17, 2006·Nature Reviews. Cancer·Lauren M F MerloCarlo C Maley
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·ChongFeng GaoGeorge F Vande Woude
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James BeanWilliam Pao
Jan 30, 2008·Nature Reviews. Genetics·Andrés Aguilera, Belén Gómez-González
Mar 28, 2008·Molecular Microbiology·Anna SelmeckiJudith Berman
Jun 19, 2008·Genetics·Eduardo M TorresAngelika Amon
Dec 9, 2008·Nature Cell Biology·Samuel F BakhoumDuane A Compton
Feb 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Silvia PolákováJure Piskur
Mar 7, 2009·PLoS Genetics·R Craig MacLean, Angus Buckling
Apr 28, 2009·Nature Medicine·Evelyne VannesteJoris R Vermeesch
May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Charles SwantonJulian Downward
Sep 29, 2009·Cancer Genetics and Cytogenetics·Joshua M Nicholson, Peter Duesberg
Feb 4, 2010·The Journal of Cell Biology·Sarah L Thompson, Duane A Compton
Feb 10, 2010·The Biochemical Journal·James A Birchler
Mar 26, 2010·Current Biology : CB·Sarah L ThompsonDuane A Compton
May 13, 2010·Molecular Systems Biology·Michael SpringerMarc W Kirschner

❮ Previous
Next ❯

Citations

Dec 27, 2011·Chromosoma·Peter C StirlingPhilip Hieter
Mar 15, 2012·Immunologic Research·Fabien Cottier, Norman Pavelka
Dec 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Avihu H YonaOrna Dahan
Jul 26, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rebecca RoylanceCharles Swanton
Nov 21, 2012·PLoS Pathogens·Kyung J Kwon-Chung, Yun C Chang
Oct 14, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Kaori MatsuzakiMasayuki Mishima
Jul 19, 2012·Annual Review of Cell and Developmental Biology·Jake J Siegel, Angelika Amon
Mar 8, 2013·Seminars in Cell & Developmental Biology·Dustin Mayfield-JonesGavin C Conant
Feb 6, 2013·Seminars in Cell & Developmental Biology·Carl A Morrow, James A Fraser
Feb 14, 2013·Seminars in Cell & Developmental Biology·Giulia Rancati, Norman Pavelka
Sep 11, 2012·Trends in Cell Biology·Kenneth B Kaplan, Rong Li
Jul 14, 2012·Trends in Parasitology·An MannaertJean-Claude Dujardin
Mar 1, 2012·Trends in Genetics : TIG·Judith Berman, Lilach Hadany
Aug 30, 2011·Trends in Genetics : TIG·Jason M Sheltzer, Angelika Amon
Oct 27, 2015·Cell·Avihu H YonaYitzhak Pilpel
Aug 29, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Guangbo ChenRong Li
Jul 28, 2015·Cell Reports·Ashley M LaughneySamuel F Bakhoum
May 28, 2015·Cell Division·Maybelline Giam, Giulia Rancati
Oct 15, 2013·FEMS Microbiology Reviews·Wahid MullaRong Li
May 6, 2015·ELife·Joshua M NicholsonDaniela Cimini
Feb 3, 2015·Journal of Microbiological Methods·Maciej WnukAnna Lewinska
Nov 7, 2015·PLoS Genetics·Karin VoordeckersKevin J Verstrepen
May 27, 2015·PLoS Biology·Anna B SunshineMaitreya J Dunham
Aug 1, 2015·Scientific Reports·Waranya NatesuntornSatoshi Harashima
May 25, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Jamal-HanjaniC Swanton
Dec 29, 2017·Cancers·Natalia Vargas-RondónMilena Rondón-Lagos
Aug 23, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Susan M RosenbergP J Hastings
Jan 1, 2013·F1000Research·Domenico NapoletaniDaniele C Struppa
Dec 18, 2015·F1000Research·Esmeralda VicedoBurkhard Rost
Oct 21, 2015·Scientific Reports·Annalisa FrattiniEmanuela Maserati
Jan 25, 2012·Nature Reviews. Genetics·David J GordonDavid Pellman
Apr 28, 2019·Molecular Biology and Evolution·Feng YangJudith Berman
Sep 15, 2012·Reports on Progress in Physics·Walter ReisnerRobert H Austin
Aug 8, 2014·FEMS Microbiology Reviews·David Gresham, Jungeui Hong
Aug 14, 2019·Reviews in Medical Virology·Fateme TaheriEbrahim Faghihloo
Sep 3, 2016·Genes & Development·Hong-Yeoul RyuMark Hochstrasser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.