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Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family

Sarcoma

Jan 5, 2011

Heinrich Kovar

Abstract

FUS, EWS, and TAF15 form the FET family of RNA-binding proteins whose genes are found rearranged with various transcription factor genes predominantly in sarcomas and in rare hematopoietic and epithelial cancers. The resulting fusion gene products have attracted considerable interest as...read more

Mentioned in this Paper

Fusion Gene
Sarcoma
Protein Family
DNA Repair
Epithelial Ovarian Cancer
TAF15 protein, human
Protein Function
TAF15 gene
Transcription factor genes
Malignant Neoplasms
Paper Details
References
  • References140
  • Citations44
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  • References140
  • Citations44
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Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family

Sarcoma

Jan 5, 2011

Heinrich Kovar

PMID: 21197473

DOI: 10.1155/2011/837474

Abstract

FUS, EWS, and TAF15 form the FET family of RNA-binding proteins whose genes are found rearranged with various transcription factor genes predominantly in sarcomas and in rare hematopoietic and epithelial cancers. The resulting fusion gene products have attracted considerable interest as...read more

Mentioned in this Paper

Fusion Gene
Sarcoma
Protein Family
DNA Repair
Epithelial Ovarian Cancer
TAF15 protein, human
Protein Function
TAF15 gene
Transcription factor genes
Malignant Neoplasms

Feeds With Similar Papers

Osteosarcoma

Osteosarcoma is the most common primary bone malignancy diagnosed in children and young adults and has a high propensity for local invasion and distant metastasis. Here is the latest research.

DNA Repair

DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.

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Paper Details
References
  • References140
  • Citations44
12345...
  • References140
  • Citations44
12345

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