Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris

BMC Genomics
Sharanya ChatterjeeUtpal S Tatu

Abstract

Candida auris is a multidrug resistant, emerging agent of fungemia in humans. Its actual global distribution remains obscure as the current commercial methods of clinical diagnosis misidentify it as C. haemulonii. Here we report the first draft genome of C. auris to explore the genomic basis of virulence and unique differences that could be employed for differential diagnosis. More than 99.5 % of the C. auris genomic reads did not align to the current whole (or draft) genome sequences of Candida albicans, Candida lusitaniae, Candida glabrata and Saccharomyces cerevisiae; thereby indicating its divergence from the active Candida clade. The genome spans around 12.49 Mb with 8527 predicted genes. Functional annotation revealed that among the sequenced Candida species, it is closest to the hemiascomycete species Clavispora lusitaniae. Comparison with the well-studied species Candida albicans showed that it shares significant virulence attributes with other pathogenic Candida species such as oligopeptide transporters, mannosyl transfersases, secreted proteases and genes involved in biofilm formation. We also identified a plethora of transporters belonging to the ABC and major facilitator superfamily along with known MDR transcriptio...Continue Reading

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Datasets Mentioned

BETA
PRJNA267757
SRX766223
SRX766234
SRX766231
LGST00000000

Methods Mentioned

BETA
Illumina sequencing
FACS
PCR
Chip
BioSample

Software Mentioned

R
InterProScan
Blast2GO
tRNAScan
Bowtie2
MEGA6
PE
Vitek
Qubit
GFFex

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