Draft Genome Sequence of a Metronidazole-Resistant Gardnerella vaginalis Isolate

Genome Announcements
Jessica A SchuylerDavid W Hilbert

Abstract

We report the draft genome sequence of a Gardnerella vaginalis strain (3549624) isolated from a vaginal specimen. G. vaginalis is associated with bacterial vaginosis, the most common cause of vaginal discharge, which is often treated with metronidazole. This isolate is highly resistant to metronidazole (MIC, 500 µg/ml) and may be useful for comparative genomic studies to determine the molecular basis of metronidazole resistance in this species.

References

Oct 1, 1984·Journal of Clinical Microbiology·P PiotK K Holmes
Dec 1, 1993·Antimicrobial Agents and Chemotherapy·A B KharsanyJ Van den Ende
Sep 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emilia H KoumansUNKNOWN CDC BV Working Group
Nov 19, 2002·Antimicrobial Agents and Chemotherapy·Ellie J C GoldsteinHelen T Fernandez
Mar 11, 2010·AIDS Patient Care and STDs·Hamish MohammedPatricia Kissinger

❮ Previous
Next ❯

Citations

Aug 6, 2020·Current Drug Targets·Graziela Vargas Rigo, Tiana Tasca

❮ Previous
Next ❯

Datasets Mentioned

BETA
LFWD00000000

Methods Mentioned

BETA
PCR

Software Mentioned

GS Reference Mapper
GS de assembler

Related Concepts

Related Feeds

Bacterial Vaginosis

Bacterial vaginosis can increase the risk of sexually transmitted infections and in rare cases lead to pelvic inflammatory diseases. Discover the latest research on Bacterial Vaginosis here.

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.