Draft genome sequence of Streptomyces sp. TP-A0882 reveals putative butyrolactol biosynthetic pathway

FEMS Microbiology Letters
Hisayuki KomakiYasuhiro Igarashi

Abstract

We report the draft genome sequence of marine-derived Streptomyces sp. TP-A0882, a producer of buryrolactol, an antifungal γ-lactone-containing polyketide. The genome harbored at least three type I polyketide synthase (PKS), three type II PKS, four nonribosomal peptide synthetase (NRPS) and two hybrid PKS/NRPS gene clusters. Annotation of gene functions enabled us to identify the type I PKS gene cluster for butyrolactol biosynthesis and propose a plausible biosynthetic pathway for this unique polyketide.

References

Jun 18, 2003·Journal of Industrial Microbiology & Biotechnology·Francesca Del VecchioPeter F Leadlay
May 6, 2006·Current Opinion in Microbiology·Kin S Lam
Apr 21, 2009·Natural Product Reports·Yolande A ChanMichael G Thomas
Mar 10, 2010·BMC Bioinformatics·Doug HyattLoren J Hauser
Dec 5, 2012·Journal of Bacteriology·Yoshiyuki OhtsuboMasataka Tsuda

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Citations

Jan 4, 2017·World Journal of Microbiology & Biotechnology·Vishnu Priya PadmanabanKirubagaran Ramalingam
Apr 7, 2017·Beilstein Journal of Organic Chemistry·Enjuro HarunariYasuhiro Igarashi

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