Draize Eye Scores and Eye Irritation Thresholds in Man Combined into one Quantitative Structure-Activity Relationship

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M H AbrahamW S Cain

Abstract

Draize eye scores (DES) for 37 pure organic liquids have been converted into scores for the corresponding vapours, DES/P(o), where P(o) is the liquid vapour pressure in ppm at 298K. It is shown that there is a constant difference (0.66) between values of log(DES/P(o)) and log(1/EIT) where EIT is the eye irritation threshold in ppm of eight vapours towards human subjects. The 37 log(DES/P(o)) values can be combined with 17 log(1/EIT) values to give one quantitative structure-activity relationship, [Formula: see text] where R(2) is an excess molar refraction, pi(2)(H) is the compound polarizability/dipolarity, Sigmaalpha(2)(H) and Sigmabeta(2)(H) are the compound hydrogen-bond acidity and basicity, and L(16) is the gas-hexadecane partition coefficient. The number of data points is n, the correlation coefficient is r, the standard deviation is sd, and F is the F-statistic. LogSP is then either [log(DES/P(o)) - 0.66], or log(1/EIT). It is suggested that equation i can be used to predict eye irritation of organic vapours and pure liquids as eye irritation thresholds.

References

Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·J E Cometto-Muñiz, W S Cain
Nov 1, 1990·Physiology & Behavior·J E Cometto-Muñiz, W S Cain
Oct 1, 1994·Journal of Pharmaceutical Sciences·M H Abraham, P K Weathersby
Sep 1, 1994·American Industrial Hygiene Association Journal·J E Cometto-Muñiz, W S Cain
Sep 1, 1993·Archives of Environmental Health·J E Cometto-Muñiz, W S Cain
May 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M H AbrahamW S Cain
Jul 1, 1997·Perception & Psychophysics·J E Cometto-MuñizH K Hudnell
May 15, 1998·Experimental Brain Research·J E Cometto-MuñizM H Abraham
Dec 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M BallsH Spielmann
Jun 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M H AbrahamW S Cain
Feb 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M T CroninM York

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Citations

May 16, 2007·Experimental Brain Research·J Enrique Cometto-MuñizRicardo Sánchez-Moreno
Sep 7, 1999·Physiology & Behavior·J E Cometto-MuñizJ M Gola
Jun 19, 2004·Journal of Occupational and Environmental Hygiene·William S CainB Dwight Culver
Oct 7, 2011·Chemical Senses·Michael H AbrahamWilliam S Cain
Feb 9, 2000·Pharmaceutical Science & Technology Today·I GroverI Bakshi
Apr 29, 2004·Critical Reviews in Toxicology·Richard L DotyMichael Hodgson
Sep 12, 2007·Journal of Pharmaceutical Sciences·Michael H AbrahamStacy Payne
Jan 25, 2002·Journal of Applied Toxicology : JAT·J Enrique Cometto-MuñizJoelle M R Gola
Nov 17, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Michael H AbrahamWilliam S Cain
Jan 25, 2005·Indoor Air·J Enrique Cometto-MuñizMichael H Abraham
Oct 4, 2014·Environmental Science & Technology·Satoshi Endo, Kai-Uwe Goss
Aug 5, 2003·Environmental Health Perspectives·Mark T D CroninAndrew P Worth
Mar 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·J Enrique Cometto-MuñizRicardo Sánchez-Moreno

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